Antidysrhythmics/CCBs
Name 2 adverse effects of Quinidine
Diarrhea, Cinchonism, Cardiotoxicity, Arterial embolism, hypotension
What is the biggest risk when taking clozapine?
Agranulocytosis - lack of WBCs
What foods should be avoided when taking selegiline
foods high in tyrosine (can cause hypertensive crisis)
What receptors does epinephrine act on?
Alpha 1/2, Beta 1/2
What is the main adverse effect of the NRTI abacavir?
Bonus 100: What are the s/s of it?
Lactic acidosis
Nausea, fatigue, hyperventilation: high CO2 lvls
What substance blocks adenosine?
caffeine
Name the symptoms of neuroleptic malignant syndrome
“Lead pipe” rigidity, sudden high fever, sweating, autonomic instability, dysrhythmias, fluctuations in blood pressure, altered level of consciousness, and seizures or coma
Adverse reactions of levodopa/carbidopa
N/V, dyskinesias, orthostatic hypotension, psychosis
What test should be done before administering clonidine?
Pregnancy test before prescribing: teratogenic
What exam is the most important when taking hydroxychloroquine?
Eye exams Q6months - causes retinal damage
What are symptoms of lidocaine toxicity?
slurred speech, altered CNS (confusion, drowsiness, restlessness), tremors, seizures
What is the treatment for severe dystonia?
anticholinergic medication (eg, benztropine or diphenhydramine) given IM or IV
What should be avoided when taking immunomodulators?
live vaccines, use with other immunomodulators
What is the highest dose of metoprolol that can be given before beta 2 receptors are activated?
100 mg
What are three adverse effects of PIs
Hyperglycemia/diabetes, lipodystrophy, Hyperlipidemia, Increased bleeding in people with hemophilia, Elevation of serum transaminase, Decreased cardiac conduction velocity, Cardiac effects- PR prolongation, bundle branch blocks., Elevated Liver function tests (LFTs)
What is the half-life of amiodarone?
60-142 days
What is the most important monitoring precaution for haloperidol?
QT interval - it can be prolonged. Avoid QT prolonging meds
What is the antidote for baclofen?
MAOIs, Tricyclic antidepressants, General anesthetics, phentolamine, beta-blockers (cause tachycardia)
What is the unique feature of HIV Fusion Inhibitors: enfuvirtide?
Must be given SubQ twice daily
Beta-blockers usually intensify the adverse effects of CCBs. Which CCB has decreased adverse cardiac effects when taken with beta blockers?
Nifedipine
How do you treat tardive dyskinesia?
Switch to a SGA, benzodiazepines, reduction in dose of FGA. Best solution is prevention
What is the MOA for dantrolene?
Acts directly on skeletal muscles and suppresses the release of calcium from the sarcoplasmic reticulum
What is the indication for prazosin?
Hypertension, BPH
What is the lab value of an HIV drug treatment that has failed after 24 weeks?
Plasma HIV RNA remains greater than 200 copies/mL