Pharmacology Final Exam

Pharm 1

100

This is the strongest type of chemical drug bond

covalent 

200

This opioid has been shown to display local anesthetic properties

Meperidine 

300

Stimulation of this nucleus sends a parasympathetic signal down the ciliary ganglion to result in miosis

Edinger Westphal

400

These three locals are said to have the greatest degree of vasoconstrictive properties

Cocaine, lidocaine, ropivacaine

500

Excitatory movements sometimes seen with propofol and etomidate are the result of this mechanism

disinhibition of subcortical centers

Pharm 2

100

Opioids primarily exert their mechanism of action on this area of the spinal cord lamina

Substantia gelatinosa 

200

An increase in this enzyme activity with increasing body weight probably accounts for the need to dose succinylcholine on TBW

plasma cholinesterase 

300

Sugammadex works on neuromuscular blockers with this type of nuclei makeup

steroidal 

400

When binding of an agonist produces a decreased response, this is said to have occurred 

desensitization 

500

30 mg of toradol has the same analgesic potency as this dose of morphine

10 mg

Pharm 3

100

This anticholinergic has the least potential to increase heart rate

scopolamine

200

Direct CNS excitation of this opioids metabolite can produce seizure activity

Meperidine

300

This is the amount that was originally given if 15 mg of a drug eliminated by first order kinetics remained after 4 half lives

240 mg

400

Of the agents enflurane, halothane, sevoflurane, and desflurane, this one is metabolized to the greatest degree 

Halothane 

500

According to OSHA, healthcare personnel should not be exposed to more than this many ppm of N2O if a halogenated agent is also used?

0.5

Pharm 4

100

Suggamadex is classified as this type of agent

selective relaxant binding agent

200

This anticholinergic agent does not cross the blood brain barrier

glycopyrolate

300

Serotonin syndrome and its associated symptoms may occur in patients taking MAOIs when combined with this opioid medication

Meperidine

400

EMLA cream contains these two local anesthetics

lidocaine and prilocaine

500

This is the plasma concentration at which half of a drugs maximal effect is seen

EC50

Pharm 5

100

This type of function is generally the last lost during onset of local anesthetic blockade

motor function

200

Local anesthetics with this property generally have a faster onset

pKa close to pH of environment placed in

300

This muscle/muscle group is generally the first to recover following neuromuscular blockade

diaphragm

400

If this factor in a drugs pharmacokinetics increased, it would have an increased duration of action, less free drug, and a higher plasma concentration.

protein binding

500

The same analgesic equivalency of 100 mcg of sufentanil can be achieved with this dose of demerol

1 gram