GI Drugs
This drug, used as an appetite stimulant in cats, has other uses as an anti-emetic and an anxiolytic; high dose side effects include vocalization and hyperactivity
This drug, used for anxiety, phobias and urine spraying, works by binding to the GABA receptor and enhancing the inhibitory effects of GABA
What is Diazepam (Valium)?
Commonly known as red death, this drug is largely excreted in the bile and has serious ADR's such as myelosuppression and cardiotoxicity
What is Doxorubicin?
This immunosuppressive drug, also used as a chemotherapeutic, works by cross-linking DNA (it's an alkylating agent)
What is Chlorambucil (Leukeran)?
This pesticide, which works via competitive inhibition of Acetylcholinesterase, is commonly found as a dusting powder for control of ectoparasites in food animals
What is Carbamates?
This drug, a dopamine & serotonin inhibitor, has uses as a prokinetic (to treat megaesophagus in dogs) and as an antiemetic
What is Metoclopramide?
This drug, used to treat anxiety states and phobias, works by inhibiting reuptake of serotonin
What is Fluoxetine (Prozac)?
This chemotherapeutic works by inhibiting Tyrosine kinase, effectively starving the tumor out (not enough blood/nutrient supply)
What is Toceranib (Palladia)?
This drug is used preemptively to reduce clinical mastitis in the first 30 days of lactation to counter neutropenia during the transition period
What is Imrestor (pegbovigrastim)?
This drug, used to kill nematodes, is a nicotinic receptor agonist, causing spastic paralysis in the nematode. It's commonly found as either a pamoate salt in paste or as a tartrate salt in solutions for drinking water
What is Pyrantel?
This drug, the most commonly used anti-emetic, is a NK1 receptor antagonist and works by blocking binding of substance P in the emetic center
What is Maropitant (Cerenia)?
This drug, used for non-specific sedation in both small and large animals, works by antagonizing D2 (dopamine) in the CNS
What is Acepromazine?
This chemotherapy drug is used as an analgesic for osteosarcoma in dogs, and works by inhibiting osteoclasts and decreasing bone resorption
What is Pamidronate?
This "drug", used to reduce pruritis in dogs with atopic dermatitis, isn't really a drug - it's a canine monoclonal antibody against IL31
What is Cytopoint (lokivetmab)?
This drug has a broad spectrum - it's effective against most nematodes, some cestodes, some trematodes, and Giardia. It works by binding to parasite B-tubulin (interfering with microtubules), and common formulations include Panacur and Safe-guard
What is Fenbendazole? (a benzimidazole)
What is Omeprazole (Gastrogard)?
This drug, classed as a SARI and used to treat anxiety disorders, works on many receptors: it's an antagonist at 5HT2, H1, and alpha 1 receptors, while it's an agonist at 5HT1
What is Trazodone?
This chemotherapeutic works by binding tubulin protein and interfering with the microtubule network
What is Vincristine?
This immunosuppressive drug works by inhibiting Janus kinase, therefore inhibiting pruritogenic and pro-inflammatory cytokines (like IL31) that are dependent on JAK1 or JAK3 activity
What is Apoquel (oclacitinib)?
This drug is commonly used prophylactically to prevent coccidiosis in cattle. It also works to improve feed efficiency in dairy cattle by killing gram + bacteria, which favors propionate production
What is Monensin (Rumensin)? (an ionophore)
This drug is used as an anti-diarrheal and works by acting on mu opioid receptors in the GIT to decrease motility, increase GI sphincter tone, and stimulate fluid & electrolyte absorption
What is Loperamide (Imodium)?
This drug, classed as a TCA and used to treat anxiety and stereotypies, inhibits reuptake of both serotonin and norepinephrine
What is Clomipramine (Clomicalm)?
This NSAID can be used to treat transitional cell (bladder) carcinoma
This immunosuppressive drug, classed as a purine inhibitor, is metabolized in the liver to an active metabolite called 6-mercaptopurine
What is Azathioprine (Imuran)?
This drug, used for flea control, works by inhibiting chitin synthesis; formulations include Program for cats & Sentinel for dogs
What is Lufenuron? (an insect development inhibitor)