It's Fine
Change Later
Fetus
Misc. Fetus
100
Withdrawal or inactivation of this hormone "awakens" or activates the uterus.
Progesterone
100
CAPS ____ the uterine responsiveness to uterotonins.
Increase
100
This uterine action is required for induction of specific CAPs. Namely, increases expression of connexin-43 and oxytocin receptors.
Stretch
Levels of gastrin-releasing peptide, a stimulatory agonist for smooth muscle, also are augmented by stretch in the myometrium
100
"The condition or process of deterioration"
Senescence
200
Through interaction with PR-B, this hormone regulates numerous genes in the oxytocin signaling pathway.
Progesterone
Which may also act within the myometrial cell to enhance oxytocin receptor degradation
200
Levels of these large, linear, polysaccharides in the cervical matrix are uniquely increased in phase 2
Glycosaminoglycans
200
The ability of the fetus to provide endocrine signals that initiate parturition has been demonstrated in several species. Therefore, premature activation of this axis is considered to prompt many cases of preterm labor
Hypothalamic-pituitary-adrenal-placental
considered a critical component of normal parturition
200
In human and animal fetal membranes, stretch and oxidative stress induce senescent fetal membrane to manifest a form of sterile inflammation termed_____.
Senescent-associated secretory phenotype (SASP).
This in turn propagates inflammatory signals that further weaken the fetal membrane and activate signals in the decidua and myometrium to initiate parturition.
300
_______ is a classic steroid antagonist, that acts at the level of the progesterone receptor, which can have a ripening effect on the cervix
Mifepristone
300
Treatment to promote cervical ripening for labor induction includes direct application of these hormone like substances.
Prostaglandins PGE2 and PGF2α,
They likely modify ECM structure to aid ripening, although their role in the normal physiology of cervical ripening remains unclear.
300
The human placenta has the unique ability to produce large amounts of this hormone, which is identical to the maternal and fetal hypothalamic versions.
corticotropin-releasing hormone (CRH)
Unlike hypothalamic CRH, which is under glucocorticoid negative feedback, cortisol instead stimulates placental CRH production
300
Some evidence shows that pregnancies with markedly diminished production levels of this hormone may be associated with prolonged gestation.
Estrogen
These include women with inherited placental sulfatase deficiency and fetal anencephaly with adrenal hypoplasia. The broad range of gestational length seen with these disorders, however, calls into question the exact role of estrogen in human parturition initiation.
400
Myometrial receptors of this hormone rise during phase 2 of parturition
Oxytocin
400
The endocervical canal is lined with mucus-secreting _____and ____squamous epithelia.
Columnar and Stratified
These cells form both a mucosal barrier and a tight junctional barrier that protect against microbial invasion
400
In pregnancies in which the fetus can be considered “stressed” from various complications, concentrations of CRH in fetal plasma, amnionic fluid, and maternal plasma are greater than those seen in normal gestation. What is likely the source of this CRH?
The placenta
For example, placental CRH content is fourfold higher in placentas from women with preeclampsia than in those from normal pregnancies
400
This protein is produced by the fetal lungs and is thought to inhibit PGF2α in the term decidua
Surfactant protein A (SP-A)
But SP-A levels drop in the amnionic fluid at term
500
Changes in the myometrium prepare it for labor contractions. Change results from a shift in proteins that control uterine quiescence to an expression of these proteins (which include the oxytocin receptor, prostaglandin F receptor, and connexin-43).
Contraction-associated proteins
500
Once labor is underway, activation of ________(WBC type), proinflammatory M1 macrophages, and tissue repair M2 macrophages in the cervix is augmented.
Neutrophils
Proinflammatory and immunosuppressive gene expression in the cervix increases markedly after delivery.
500
What is my favorite color?
Blue
500
This is the name of the orange cat I own
Calcifer