Acute Inflammation
Cell injury/death
Neoplasia
Hemodynamics
Genetics
Met/Nutr
Genetics
100

J: Which toll like receptor only leads to the production of INF-?

  • TLR1
  • TLR2
  • TLR3
  • TLR4

Ji better know this

100

S: Which is a characteristic of reversible cell injury? 

  • Cellular swelling
  • Nuclear fragmentation
  • Plasma membrane rupture
  • Enzymatic digestion of the cell

Sarah better know this... or else

100

K: Which molecule does PTEN inhibit?

  • p53
  • AKT
  • ERK
  • PI3K

Kristin better know this one.

100

J: Which chromosomal abnormality results in a loss of material?

  • Pericentric inversion
  • Paracentric inversion
  • Robertsonian translocation
  • Isochromosomic separation

Ji knows dis

100

S: A mutation that replaces the normal amino acid with a biochemically different one is classified as:

A nonsense mutation

A frameshift mutation

A conservative missense mutation

A nonconservative missense mutation

Sarah, giggity

200

S: Transcytosis across endothelial cells is induced by:

  • NO
  • PAF
  • VEGF
  • Histamine

Sarah better know this...

200

S: What is the initiator caspase for the intrinsic pathway of apoptosis?

  • Caspase-1
  • Caspase-3
  • Caspase-8
  • Caspase-9

Sarah got dis

200

S: What transcription factor controls epithelial-mesenchymal transition (EMT)?

  • RB
  • SNAIL
  • PTEN
  • E-cadherin

Sarah, yeet

200

K: What factor(s) converts prothrombin into thrombin?

  • XI
  • VIII
  • V and X
  • III and VII

Kristin got it

200

K: What enzyme is defective with Tay Sachs disease/GM2 gangliosidosis/Sandhoff?

  • β-galactosidase
  • α-mannosidase
  • Hexosaminidase A
  • Galactosylceramidase

Kristin makes sourdough bread

300

K: What integrin is expressed by dendritic cells?

  • α4β7
  • LFA-1
  • VLA-4
  • MAC-1

Kristen knows this one.

300

K: What protein(s) accomplish MOMP (mitochondrial outer membrane permeability)?

  • BCL-2
  • APAF-1
  • BAX/BAK
  • SMAC/Diablo

Kristin better know this.

300

J: Which gene is an inhibitor of TGF-B signaling?

  • APC
  • PTEN
  • SMAD2
  • CDKN2A

Ji knows this

300

J: Which factor activation requires thrombin?

  • Factor V
  • Factor IX
  • Factor VII
  • Factor XII

Ji got dis

300

J: Which hormone promotes increased food intake?

  • Leptin
  • Amylin
  • Ghrelin
  • Adiponectin

Ji, wila-kers

400

S: Which complement pathway is activated by cobra venom?

  • Lectin
  • Classical
  • Alternative

Sarah better know this one.

400

J: Which molecule is the bridge between extrinsic and intrinsic apoptosis pathways?

  • BAX
  • BID
  • MCL1
  • PUMA

Ji knows this one.

400

J: Which receptor tyrosine kinase is activated first in the MAPK pathway?

  • Raf
  • ERK
  • JNK
  • MEK

Ji, HAW

400

S: Upon endothelial damage, vWF forms a collagen bridge with which platelet receptor?

GPIb

GPVI

GPIa-IIa

GPIIb-IIIa

Sarah, GORL

400

K Which enzyme in iron metabolism is copper a cofactor for?

  • Hephaestin
  • Ferroxidases
  • Ceruloplasmin 
  • Ferrireductases

Kristin, ZOOP

500

K: What is inhibited in the presence of Death Accelerating Factor (DAF)?

  • Binding of IgM and C1
  • Formation of C3 convertase
  • Formation of membrane attack complex (MAC)
  • Binding of mannose and mannose binding lectin

Kristin better know this one.

500

K: What is the signaling ligand for the canonical necroptosis pathway?

  • TNF
  • Fas-L
  • IFN-g
  • Death receptor ligand

Kristin knows this one... probably

500

K: What is the cellular effect of binding of Wnt to the Frizzled cell receptor?

  • Increased cAMP
  • Cleavage of Notch
  • Amplification of MAPK
  • Migration of β-catenin to the nucleus

Kristin knows dis

500

J: Which is stored in dense granules of platelets?

  • VWF
  • P-selectin
  • Fibrinogen
  • Histamine

uh, Ji?

500

S: 1,25-dihydroxyvitamin D stimulates osteoclast activity via upregulation of what transcription factor?

TRPV5

TRPV6

RANKL

CYP27B

HELP! Sarah FORCED ME TO DO THIS

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