Dynamic Kinetics
This is known as "what the drug does to the body"
Pharmacodynamics
How does one get natural active acquired immunity to a virus?
Get infected and recover from the virus
What does "MMR" stand for?
What is the brand name for the influenza nasal vaccine?
FluMist
Monoclonal antibody drugs end with these 3 letters.
MAB
This organ is responsible for the "first pass effect"
LIVER
How does one get natural passive acquired immunity?
Breastfeeding or pregnancy (mother to fetus)
What illness was the first vaccine ever developed used for?
Smallpox
If a patient has a mild scratchy throat, mild stuffy nose, mild cough and no fever, what type of URTI do they most likely have?
common cold
What drug class does the drug sirolimus (Rapamune) belong to?
mTOR Kinase Inhibitors
What is the route of administration that produces the best bioavailability?
Intravenous drug delivery
These 2 types of immune cells are "first responders".
Neutrophils and macrophages
What are 2 contraindications for a live vaccine?
Pregnancy or severely immunocompromised (could also include allergy history to vaccine component)
When does influenza peak in Canada (name the 5 months)
November to March
What drug class does azathioprine (Imuran) belong to?
Anti-metabolites
What is a pro-drug?
Medication that is inactive but when taken is metabolized into an active form.
What type of drug can cause low neutrophils?
Chemotherapy
How long should a patient wait in a pharmacy after getting a vaccine? GIVE THE ENTIRE RANGE.
15 to 30 minutes
How many strains of influenza do most flu vaccines contain? How many of them are influenza A? How many are influenza B?
2 + 2 = 4
Nephrotoxicity (kidney toxicity) is a problem with this class of drug even though they are used to prevent rejection of organ transplant (including kidney transplant).
*Name the class or a drug
Calcineurin Inhibitors (cyclosporine + tacrolimus)
Name the 3 organs with the highest blood supply (and therefore the best drug distribution)
Heart, Brain and Kidneys
What are the 3 antigen presenting cells?
Dendritic cells; Macrophages; B-Cells
What are the 3 public health vaccines recommended for adults (excluding influenza/covid)?
DTAP (every 10 yrs + each pregnancy); Pneumococcal (one dose once 65+); RSV (60+ in LTC or 75+ all)
What are 3 brand names for the inactivated influenza vaccine?
Fluzone; Flulaval; Afluria
What adverse effect do all immunosuppressive drugs have in common?
Increased risk of infection