Placenta
Common medication that does not cross the placenta used in GDM
What is insulin?
Folic Acid's drug category
What is Category A?
This psychoactive substance is fat soluble
What is THC?
IgG
What is the immunoglobulin that crosses the placenta?
The study of how the body interacts with administered substances for the entire duration of exposure
What is pharmacokinetics?
Class of medications used by anesthesia that does not cross the placenta
What is paralytics?
Methotrexate's drug classification
What is category Category X?
A powerful vasoconstrictor associated with placental abruption
What is cocaine
Type of adjustment hypothyroid medications require in pregnancy
What is an increase?
The movement of drug from the site of administration into the systemic circulation
What is drug absorption?
Anticoagulants that do not cross the placenta
What are Heparin and Lovenox?
Levothyroxine drug classification
What is Category A?
Cross placenta and cause neonatal respiratory depression
What are Opioids?
Anticoagulant med who's peak can be checked 4 hours after administration for therapeutic dosing
What is Lovenox?
The ratio of the amount of drug in a body (dose) to concentration of the drug that is measured in blood/plasma.
What is volume of distribution?
These two glucocorticoids are the only two known to cross the placenta
What are Betamethasone and Dexamethasone?
Coumadin's drug classification
What is Category D?
Long acting opioid medications (MAT) used to treat opioid use disorder
What are Methadone and Suboxone?
Antibiotics that exhibit increased renal elimination in pregnancy
What are cefazolin and clindamycin?
Kidneys, liver, skin, lungs, glandular structures (salivary, lacrimal, milk)
What are key organs involved in drug elimination?
These two thyroid medications cross the placenta and both have (different) teratogenic effects?
What are PTU & Methimazole?
Many drugs fall into this category as "risk cannot be ruled out"
What is Category C?
Due to rapid metabolism in pregnancy, this medication to treat illicit abuse may require twice daily dosing by the third trimester
What is methadone?
Antibiotics, antiretrovirals, steroids cross placenta (by active which active transporter)
What are examples of drugs transported by P-gp?
MRP, P-glycoprotein, BCRP, OAT1
What are placental drug transporters?