DRUG DISPOSITION
BIO 101
METABOLISM I
METABOLISM II
MISC.
100
the transfer of a drug from an administered drug product into the blood.
What is Absorption
100
the comparison of bioavailability between two dosage forms
What is Bioequivalency
100
an abbreviation for the disposition of a drug
What is ADME
100
when different molecules associate or attach to each other
What is Complexation
100
The amount of time it takes for the blood concentration of a drug to decline to one-half an initial value.
What is half life
200
Movement of drug within the body once the drug has reached the blood.
What is Distribution
200
the amount of an administered dose that reaches the general circulation and the rate at which this occurs.
What is Bioavailabilty
200
TThe effect that the body has on a drug
What is Pharmacokinetics
200
unbound drug. The form of a drug that can move through tissue membranes
What is Free Drug
200
The time needed to essentially remove a drug from the body
What is 5 half lives
300
The body’s process of transforming drugs
What is Metabolism
300
bioavailability of a drug product compared to the same drug in a rapidly administered IV solution
What is Absolute Bioavailability
300
The effect a drug has on the body
What is Pharmacodynamics
300
a complex protein that catalyzes chemical reactions
What is an Enzyme
300
the time a drug will stay in the stomach before it is emptied into the small intestine.
What is Gastric Emptying Time
400
The process of removing drugs and their metabolites from the body. Primary performed by the kidney's through the urine.
What is Excretion
400
the bioavailability of a drug product compared to the same drug in any other dosage form than a rapidly administered IV solution
What is Relative Bioavailability
400
the substance resulting from the body’s transformation of an administered drug
What is Metabolite
400
a graph used to show the concentration of drug in the blood over time. This is then used to monitor the drug concentration in the blood that correlates with the desired clinical effect of the drug.
What is the blood concentration-time curve
400
result when a week acidic drug dissociates in solution. These drugs associate with water molecules to form large particles that do not penetrate cell membranes well
What is ionized drugs
500
The collective term for metabolism and excretion.
What is Elimination
500
a complex body structure composed of lipids and proteins
What is Biological Membranes
500
The number of ml of the body that is cleared of a drug in one minute or one hour (ml/min, ml/hr) abbreviated CL
What is Total Body Clearance (CL ml/min, ml/hr)
500
drug’s blood concentration range between its MEC and MTC
What is the Therapeutic Window
500
To deliver the right drug, in the right concentration, to the right site of action at the right time to produce the desired effect.
What is The Objective of Therapy/ The Goal of Therapy
M
e
n
u