Tumor Basics/ Fundamentals
As tumors grow in confined spaces, this type of mechanical load builds up and can inhibit further expansion.
What is solid stress?
This quantity describes internal resistance that develops when a material is deformed.
What is stress?
Cells detect and respond to physical forces through this process.
What is mechanotransduction?
The deformation of the surrounding tissue by tumor expansion can collapse these structures.
What are blood and lymphatic vessels?
The change in shape or size of a material due to applied forces is known as this.
What is strain?
The cell structure that primarily resists deformation and transmits mechanical forces is the ______.
What is the cytoskeleton?
Solid stress can slow tumor growth by altering this physical property of individual cells.
What is cell size?
The relationship between stress and strain in linear elastic materials is defined by this law.
What is Hooke’s Law?
High compressive stress can reduce this cellular process essential for growth.
What is cell proliferation (division)?
The balance between nutrient diffusion and mechanical confinement determines this feature of tumor spheroids.
What is the maximum spheroid size?
The material property that measures resistance to shape change is the ______ modulus.
What is the shear modulus?
True or False: Cells behave as incompressible fluid bags.
False, their mechanical behavior depends on the cytoskeleton.
Chemical factors that facilitate tumor invasion into surrounding tissue.
What are matrix metalloproteinases?
The ratio of lateral contraction to longitudinal extension in a stretched material is called this.
What is Poisson’s ratio?
In the context of tissue mechanics, smaller daughter cells produced under compression indicate this type of feedback.
What is stress-dependent growth regulation?