Ancient Diseases
Hematology
Cardiology Trials
Pharmacology
Infiltration
100
This diagnosis is what some have suggested is how David was able to kill Goliath because the GIANT had poor peripheral vision.
Acromegaly
100
This bleeding disorder is associated with menorrhagia
Von Willebrand disease
100
Dapagliflozin reduced the combined risk of worsening HF or CV death among pts with HF and a mildly reduced or preserved EF in this trial
DELIVER TRIAL
100
This medication has been shown to reduce mortality in patients with transthyretin amyloid cardiomyopathy
Tafamadis (Vyndamax) - notably acoramidis did not reduce mortality
100
Which type of amyloidosis is associated with carpal tunnel syndrome
Transthyretin amyloidosis or ATTR
200
This metabolic disease was once treated with a bituminous medication containing silica and benoates from the Himalayas
Diabetes Mellitus
200
This hereditary autosomal dominant thrombophilia leads to increased risk of warfarin-induced skin necrosis
Protein C or S deficiency
200
This trial showed that preventive PCI of focal non-FFR-positive plaques that are angiographically >50% and have evidence of vulnerability on intravascular imaging along with optimal medical therapy is superior to optimal medical therapy alone for clinical outcomes at 2 years
PREVENT TRIAL
200
This anti-arrhythmic agent is used in the management of patients with Brugada syndrome
- Quinidine
200
This imaging finding on cardiac MRI, characterized by diffuse late gadolinium enhancement that spares the mid-myocardial layer of the basal inferolateral wall, is highly suggestive of cardiac sarcoidosis
the "ring sign" or "sarcoid ring"
300
This parasite was the cause of the space-occupying lesion in the brain of mummy 22940 in the Manchester Museum Mummy Collection
Hydatid disease (cerebral echinococcosis)
300
This type of RBC morphology is commonly seen in Liver disease, vitamin E deficiency, and abetalipoproteinemia
Acanthocytes or “Spur Cells”
300
In pts with acute MI and anemia, a liberal transfusion strategy did not significantly reduce the risk of recurrent MI or death at 30 days in this trial
MINT TRIAL
300
Adalimumab is an FDA-approved treatment for which inflammatory skin disorder of the apocrine glands
Hidradenitis suppurativa
300
This rare infiltrative cardiomyopathy is caused by the deposition of oxalate crystals in the myocardium and is often associated with end-stage renal disease or genetic disorders of oxalate metabolism.
cardiac oxalosis
400
This tropical disease was what Homer called Dog Star fever
Malaria
400
This disease presents with abdominal pain, dark red urine, neuropathy, psychological disturbances. Symptoms precipitated by p450 inducers, alcohol, or starvation
Acute intermittent porphyria
400
in subclinical atrial fibrillation, apixaban resulted in a lower risk of stroke or systemic embolism than aspirin but a higher risk of major bleeding in this trial.
ARTESIA TRIAL
400
The efficacy of doxycycline in treating Oncocerciasis is due to its symbiotic relationship with this bacterium
Wolbachia (endosymbiotic bacterium required for the survival of the adult O. volvulus worm)
400
This inflammatory infiltrative disease is characterized by findings of dense lymphoplasmacytic infiltrate and storiform fibrosis on pathology
IgG4-related disease
500
This was first noted in Minamata Bay in Japan in the 1950s when villagers were found to have severe nervous system issues including numbness of limbs, trouble hearing or seeing and severe brain damage
Mercury poisoning, also known as Minamata disease
500
This syndrome is characterized by thromocytopenia, eczema, and increased risk for infection
Wiskott-Aldrich syndrome
500
In atrial fibrillation, apixaban was superior to warfarin in preventing stroke or systemic embolism, caused less bleeding, and resulted in lower mortality in this trial
ARISTOTLE TRIAL
500
The toxicity of this chemotherapeutic agent is increased in Gilbert syndrome
Irinotecan
500
This infiltrative disease can be a rare cause of diagnosed bilateral facial palsy
Sarcoidosis