WHY CUSTOMERS CARE
The main reason to use a prefilter
What is protection?
This filtration regime captures particles larger than ~0.1 µm
What is microfiltration?
Profile, Profile Star, and HDC filters are primarily made of this material
What is polypropylene (PP)?
HDC II
What is polypropylene?
This filter type is used to remove large particles and debris (>1 µm) during clarification steps
What are depth filters (e.g., Profile II or HDC II)?
Prefilters extend the life of this expensive downstream component
What are sterilizing-grade (final) filters?
Where can a prefilter be placed in a biotech process?
Pre and post: chromatography, TFF or final filtration?
This membrane type depth filter is known for very high dirt-holding capacity
What is Profile II?
PreFlow
What is Glass Fiber?
A customer is filtering cell culture media and wants to reduce microbial contamination before sterile filtration
What is a bioburden reduction filter (e.g., Supor EAV or DBL)?
By what mechanism do prefilters improve sterilizing filtration
What is reducing particle load? (or interception)
These filters reduce microbial load prior to sterile filtration
What are bioburden reduction filters?
Polypropylene with slight hydrophobicity
What is HDC II?
Profile II
What is depth style polyproplyene?
A customer is filtering a viscous buffer at high flow rates and needs maximum throughput
What is Profile Ultipleat?
Prefilters are typically sized based on this parameter
What is capacity or throughput?
DAILY DOUBLE
Monitoring differential pressure prevents this issue
Which nylon-based filter uses charge for endotoxin removal
What is Posidyne?
Ultipleat Profile
What is Profile but Ultipleated?
A process requires removal of fine haze and turbidity
What is a fine depth or glass fiber filter (Preflow or Starclear)?
Name two key business drivers for using prefiltration
What are cost reduction, throughput improvement, bioburden reduction, clarification, or compliance?
Difference between nominal and absolute ratings
What is absolute ratings are based on validated removal efficiency while nominal ratings are not?
DAILY DOUBLE
Protection for Virus filters
Ultipor GF
What is Glass Fiber with a positive charge?
The customer is having high pressure issues with their sterilizing grade filter and needs help
What is call MSAT?