Fight or Flight Pharm
Cutting the (Vagus) Chord
Sympathetic Shutdown
Under Pressure
Water Works
100

This catecholamine shifts from predominantly β‑activity at low doses to α‑dominant effects as the dose rises, making it both an inotrope and a vasoconstrictor depending on context.

What is epinephrine?

100

This medication blocks muscarinic receptors and is first‑line for symptomatic bradycardia unless the rhythm originates below the AV node.

What is atropine?

100

This β‑1–selective blocker has an extremely short half‑life, making it ideal for rapidly titrating heart rate control.

What is esmolol?

100

This dihydropyridine calcium channel blocker is commonly used for hypertensive emergencies and has a 5–10 minute onset.

What is nicardipine?

100

This loop diuretic reduces preload through venodilation even before diuresis begins.

What is furosemide?

200

This vasopressor is considered first‑line in distributive shock because of its strong α‑1 activity and modest β‑1 support, but it should be avoided in untreated hypovolemia.

What is norepinephrine?

200

Atropine is ineffective in these two bradyarrhythmias because the block occurs distal to the AV node.

What are Mobitz II and third‑degree heart block?

200

This nonselective β‑blocker also blocks α‑1 receptors, making it useful in hypertensive emergencies.

What is labetalol?

200

This ultra‑short‑acting CCB has a half‑life of about one minute, allowing extremely fine blood pressure control.

What is clevidipine?

200

This loop diuretic is significantly more potent than furosemide on a milligram‑to‑milligram basis.

What is bumetanide?

300

This synthetic agent is known as an “inodilator” because it boosts contractility while often reducing afterload due to β‑2–mediated vasodilation.

What is dobutamine?

300

This neuromuscular disorder is a relative contraindication to atropine because it may precipitate a dangerous crisis.

What is myasthenia gravis?

300

This β‑blocker is uniquely helpful in thyroid storm because it inhibits peripheral conversion of T4 to T3.

What is propranolol?

300

This potent vasodilator carries a black box warning for cyanide accumulation, especially at high doses or prolonged infusions.

What is nitroprusside?

300

High‑dose loop diuretics may cause this reversible auditory complication.

What is ototoxicity?

400

This pure α‑agonist is sometimes used in spinal shock but may worsen cardiac output due to its lack of β‑activity.

What is phenylephrine?

400

Atropine toxicity can cause this CNS effect, particularly in older adults or those sensitive to anticholinergics.

What is delirium or acute psychosis?

400

This class of β‑blockers should be avoided in asthma or COPD because they antagonize β‑2 receptors in bronchial smooth muscle.

What are nonselective beta blockers?

400

This antihypertensive is contraindicated in pregnancy due to teratogenic effects and may cause bradykinin‑mediated angioedema.

What is enalaprilat?

400

Loop diuretics commonly cause this electrolyte abnormality, which increases the risk of ventricular arrhythmias.

What is hypokalemia?

500

This inotrope improves contractility without increasing heart rate due to it's unique mechanism of action.

What is milrinone?

500

Atropine reverses muscarinic symptoms in poisonings involving this enzyme‑inhibiting mechanism.

What is acetylcholinesterase inhibition?

500

This is the arrhythmia that may be worsened by beta blockers by diverting electrical impulses down an accessory tract.  

SVT (specifically antidromic AVRT)

500

This direct arterial vasodilator is often used in pregnancy‑related hypertension but may cause reflex tachycardia and fluid retention.

What is hydralazine?

500

Patients with this drug allergy may have cross‑reactivity with loop diuretics due to structural similarities.

What is a sulfonamide allergy?

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