Epidemiology
Who has a higher chance of having hereditary hemochromatosis: Silvia from Chile, Ansa from Finland, or Mark from the United States?
Who is Ansa? (Northern European)
Do the intestines absorb more or less iron in HCT?
What is more? (The mutation causes abnormal iron sensing and increases intestinal absorption of iron)
Deposition of iron in the joints, especially hands, leads to what common complication
What is arthropathy?
This is known as the Gold Standard treatment for Hemochromatosis.
What is a scheduled phlebotomy?
What historical crisis has been blamed for giving iron-loaded people a biological advantage?
What are the Irish potato famine and bubonic plague?
In hemochromatosis, iron accumulates in several organs. Name three.
What are liver, pancreas, skin, heart, pituitary, joints?
This is the classic triad of HCT
What are cirrhosis, diabetes, and bronze skin?
These are two things that HCT patients are advised to stay away from
What are vit C, alcohol, raw shellfish, or iron supplements?
Hemochromatosis is an autosomal recessive condition. Which gender is the clinical disease more common in?
What are men? (Even though the numbers of homozygous males and females are about equal, disease manifestation is less common in females because of menses and pregnancy.)
What is the inheritance of HCT?
What is recessive mutation on HFE gene? (C282Y >H63D, chromosome 6)
In the heart, these are the two most common manifestations
What are heart failure and arrhythmia?
HCT patients are advised to stay away from raw shellfish. What two bacteria found in shellfish are these patients susceptible for infection to?
What are Vibrio vulnificus and Salmonella enteriditis?