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Potpourri
100
In patients with nonvalvular atrial fibrillation and at ≥1 risk factor, this trial found apixaban to be associated with a greater reduction in rates of stroke or systemic embolism while having a lower rate of lower bleeding than warfarin.
What is the ARISTOTLE trial
100
In patients with non-valvular AFib, this trial found no survival benefit in rate vs. rhythm control
What is the AFFIRM trial
100
Define X: X = 1/ARR
What is NNT
100
Calculate ARR: All-cause mortality 5.7% vs. 8.3% (HR 0.68; 95% CI 0.57-0.82; P<0.001)
What is 0.026
100
In this trial among patients with low- and intermediate-risk atrial fibrillation receiving anticoagulation and undergoing an invasive procedure, periprocedural bridging anticoagulation with LMWH did not reduce the incidence of arterial thromboembolism when compared to no bridging, but did increase the risk of major bleeding.
What is the BRIDGE trial
200
This was a noninferiority trial evaluating apixaban and warfarin in PE/VTE patients.
What is the AMPLIFY trial
200
This trial showed that patients with hypertension, chlorthalidone, amlodipine, and lisinopril performed similarly in regards to fatal CAD and nonfatal MI
What is the ALLHAT trial
200
This is the ability of a test to correctly identify those with the disease (true positive rate)
What is Sensitivity
200
Calculate NNT CV mortality or HF hospitalization 21.8% vs. 26.5% (HR 0.80; 95% CI 0.73-0.87; P<0.001)
What is 21
200
Patients with T2DM at increased risk for CVD, liraglutide was associated with a reduction in CV events when compared to placebo.
What is the LEADER trial
300
This study demonstrated that compared to warfarin, high-dose dabigatran reduces stroke risk without increasing the risk of major bleeding among patients with atrial fibrillation
What is the RE-LY trial
300
This trial showed intensive BP control improved CV outcomes and overall survival compared to standard therapy In patients at high risk for CVD but who do not have a history of stroke or diabetes.
What is the SPRINT trial
300
Statistical analysis demonstrating the maximum effectiveness of a new medication when used correctly.
What is per protocol analysis
300
The mean age of 100 patients receiving the new therapy is 40 years old, and the standard deviation is 4 years. Assuming normal distribution, calculate the percentage of patients is expected to be between 32 and 48 years of age?
What is 95%
300
This trial showed that among patients with schizophrenia, patients, receiving olanzapine experienced a longer time to discontinuation compared with the other antipsychotic medications, but they experienced greater weight gain, hyperglycemia and hyperlipidemia.
What is the CATIE trial
400
These two DOACs were compared in the first head-to-head trial to compare risks of thromboembolic stroke, intracranial hemorrhage (ICH), major extracranial bleeding including major gastrointestinal bleeding, and mortality in patients with nonvalvular AF.
What is rivaroxaban (Xarelto) and dabigatran (Pradaxa)
400
This trial showed that in patients with prior stroke/TIA, atorvastatin reduces risk of recurrent ischemic stroke, but may increase risk of hemorrhagic stroke.
What is the SPARCL trial
400
Statistical test for un-paired nominal data when N < 20
What is the Fisher's exact test
400
In a cohort study designed to determine an association between measles/mumps/rubella vaccination and autism, investigators report the relative risk of autistic disorder in the vaccinated group compared to the unvaccinated group as 0.92 (95% CI = 0.65 –1.07) Estimate the p value.
What is p >0.05
400
This trial concluded that the addition of aspirin to clopidogrel therapy in patients with prior ischemic CVA or TIA did not reduce rates of recurrent ischemic CVA or TIA or related complications. Combination therapy conferred a great risk of major bleeding, including life-threatening hemorrhage.
What is the MATCH trial
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