Brand vs Generic
What is the generic name for Humira?
A) Etanercept
B) Adalimumab
C) Infliximab
D) Ustekinumab
B) Adalimumab
What cytokine does adalimumab (Humira) inhibit?
A) IL-17
B) IL-23
C) TNF-α
D) IL-12
C) TNF-α
What is the loading dose of adalimumab (Humira) for plaque psoriasis?
A) 40 mg subcutaneously on day 1
B) 80 mg subcutaneously on day 1, followed by 40 mg one week later
C) 160 mg subcutaneously on day 1
D) 80 mg subcutaneously every 2 weeks
B) 80 mg subcutaneously on day 1, followed by 40 mg one week later
TNF-α inhibitors are contraindicated in patients with which cardiac condition?
A) Hypertension
B) Congestive heart failure
C) Atrial fibrillation
D) Coronary artery disease
B) Congestive heart failure (Advanced: NYHA Class III or IV)
What is the typical route of administration for most psoriasis biologics?
A) Oral
B) Intravenous
C) Subcutaneous injection
D) Intramuscular injection
C) Subcutaneous injection
What is the brand name for secukinumab?
A) Stelara
B) Taltz
C) Cosentyx
D) Tremfya
C) Cosentyx
What is the mechanism of action of secukinumab?
A) TNF-α inhibitor
B) IL-17A inhibitor
C) IL-23 inhibitor
D) IL-12/23 inhibitor
B) IL-17A inhibitor
What is the recommended starting dose regimen for etanercept (Enbrel) in adults with plaque psoriasis?
A) 25 mg once weekly for 12 weeks
B) 50 mg once weekly for 12 weeks
C) 50 mg twice weekly for 12 weeks
D) 25 mg twice weekly for 12 weeks
C) 50 mg twice weekly for 12 weeks
Which class of biologics is associated with mucocutaneous candidiasis?
A) TNF-α inhibitors
B) IL-17 inhibitors
C) IL-23 inhibitors
D) IL-12/23 inhibitors
B) IL-17 inhibitors
How often is ustekinumab (Stelara) administered after the loading doses?
A) Every 2 weeks
B) Every 4 weeks
C) Every 8 weeks
D) Every 12 weeks
D) Every 12 weeks
What is the generic name for Skyrizi?
A) Guselkumab
B) Risankizumab
C) Tildrakizumab
D) Mirikizumab
B) Risankizumab
Which biologic inhibits the p40 subunit shared by both IL-12
and IL-23?
A) Guselkumab (Tremfya)
B) Ustekinumab (Stelara)
C) Risankizumab (Skyrizi)
D) Ixekizumab (Taltz)
B) Ustekinumab (Stelara)
What is the recommended dosing schedule for infliximab (Remicade) in plaque psoriasis?
A) 5 mg/kg IV at weeks 0, 2, and 6, then every 8 weeks
B) 3 mg/kg IV at weeks 0, 2, and 6, then every 6 weeks
C) 10 mg/kg IV at weeks 0 and 4, then every 12 weeks
D) 5 mg/kg IV at week 0 only, then every 4 weeks
A) 5 mg/kg IV at weeks 0, 2, and 6, then every 8 weeks
IL-17 inhibitors should be used with caution or avoided in patients with which gastrointestinal condition?
A) Gastroesophageal reflux disease
B) Peptic ulcer disease
C) Inflammatory bowel disease
D) Irritable bowel syndrome
C) Inflammatory bowel disease
What should patients be counseled about regarding live vaccines while on biologic therapy?
A) Live vaccines have no interaction
B) Live vaccines should be avoided
C) Live vaccines require dose adjustment
D) Live vaccines are only safe with IL-23 inhibitors
B) Live vaccines should be avoided
What is the brand name for brodalumab?
A) Siliq
B) Cosentyx
C) Taltz
D) Ilumya
A) Siliq
Which biologic targets the IL-17 receptor A rather than the IL-17 ligand itself?
A) Secukinumab (Cosentyx)
B) Ixekizumab (Taltz)
C) Bimekizumab (Bimzelx)
D) Brodalumab (Siliq)
D) Brodalumab (Siliq)
What is the maintenance dosing interval for guselkumab (Tremfya) after the initial loading doses?
A) Every 4 weeks
B) Every 6 weeks
C) Every 8 weeks
D) Every 12 weeks
C) Every 8 weeks
Which biologic has a boxed warning for suicidal ideation and behavior?
A) Adalimumab (Humira)
B) Secukinumab (Cosentyx)
C) Brodalumab (Siliq)
D) Ustekinumab (Stelara)
C) Brodalumab (Siliq)
How should biologics be stored?
A) At room temperature
B) Refrigerated
C) In the freezer
D) In a cool, dry place
B) Refrigerated (2-8°C)
What is the generic name for Ilumya?
A) Tildrakizumab
B) Guselkumab
C) Risankizumab
D) Mirikizumab
A) Tildrakizumab
What is unique about bimekizumab's (Bimzelx) mechanism
of action compared to other IL-17 inhibitors?
A) It inhibits only IL-17A
B) It inhibits only IL-17F
C) It inhibits IL-17A and IL-17F
D) It inhibits IL-17 and IL-23
C) It inhibits IL-17A and IL-17F
What is the complete loading dose regimen for bimekizumab (Bimzelx) in plaque psoriasis?
A) 320 mg at weeks 0, 4, 8, 12, and 16, then every 8 weeks
B) 320 mg at weeks 0, 2, 4, 6, and 8, then every 4 weeks
C) 160 mg at weeks 0, 1, 2, 3, and 4, then every 8 weeks
D) 320 mg at week 0, then every 4 weeks
A) 320 mg at weeks 0, 4, 8, 12, and 16, then every 8 weeks
How long should antituberculosis treatment be initiated before starting a biologic in patients with latent TB?
A) 2 weeks
B) 1 month
C) 3 months
D) 6 months
B) 1 month
Antituberculosis treatment for latent TB should be initiated at least 1 to 2 months before starting a biologic agent to reduce the risk of reactivation.
What is the loading dose regimen for secukinumab (Cosentyx) in adults with plaque psoriasis?
A) 150 mg once, then maintenance
B) 300 mg once per week for 5 weeks
C) 300 mg every 2 weeks for 3 doses
D) 450 mg once, then maintenance
B) 300 mg once per week for 5 weeks