I get off on burning houses
This disorder is characterized by the recurrent, deliberate, and purposeful setting of fires
What is pyromania?
Differentiate from arson -> No financial gain, revenge, not planned
Slide 36
Smoking is associated with most forms of this cancer
What is lung cancer?
70% of cases
This route of opioid administration has the highest overdose risk
What is IV?
Slide 23, under "Key risks"
This is the more common drug name for synthetic cathinones
What are bath salts?
Mixed mechanisms: Blocks DAT and SERTThis self-assessment is used as a screening test for possible cannabis use disorder
What is the CUDIT-R?
8+ -> hazardous use
12+ -> possible use disorder
Slide 22 and 23
Kleptomania is more commonly seen in this gender
What is female?
Slide 47
This is how many criteria are needed to classify a patient's substance use disorder as moderate
What are 4 or 5 criteria?
2-3: Mild
6+: Severe
Remission:
3-11.99 months: Early
12+: Sustained
Starting in 2000, physicians with an X-waiver could prescribe this partial opioid receptor agonist for opioid use disorder
What is buprenorphine?
Slide 14
Caffeine acts as an antagonist on this receptor
What is adenosine?
Blocks A1 and A2A
Slide 13
This ocular sign is the hallmark sign of PCP intoxication
What is a nystagmus?
Cannabis -> Conjunctival injection
LSD -> Visual/auditory disortions
MDMA ->Emotional openness/feeling close, Bruxism
Psilocybin -> Mystical experiences
Slide 70
This is the minimum age required to diagnose Intermittent explosive disorder
What is 6 years old?
Slide 34
The mesolimbic pathway connects this region of the brain to this other region of the brain
What is the VTA to the nucleus accumbens?
Mesocortical: VTA to prefrontal cortex
This synthetic opioid is 10,000 times more potent than morphine and is thus lethal in microgram doses
What is carfentanil?
Slide 22
MDMA use chronically impairs the storage and synthesis of this neurotransmitter
What is serotonin?
Also causes loss of SERT sites in the brain
Slide 53
CBD mainly activates CB2 receptors, which are found on this cell type
What are immune cells?
Also found on other organs
THC -> CB1 in the brain (mediates addiction response)
Slide 7
These are 2 of the 3 subtypes of oppositional defiant disorder
What are Angry/Irritable mood, Argumentative/defiant behavior, and Vindictiveness?
Remember that symptoms have to be exhibited during interaction with at least one individual that is not a sibling
Slide 5
This partial nicotinic receptor agonist is helpful in the management of smoking cessation
What is varenicline?
Monitor signs/symptoms of depression and suicidality
Methadone can cause this serious cardiac side effect
What is QT prolongation?
Slide 34
Along with SLC6 monoamine transporters, methamphetamine acts on this other transporter
What is VMAT2?
Slide 40
Mescaline is classified as this type of hallucinogen
What is a serotonergic hallucinogen?
SH (5-HT2 agonists) -> Mescaline, Psilocybin, LSD, DMT
Dissociatives (NMDA antagonists)->PCP, Ketamine, DMX
Entactogens (Releases endogenous monoamines) -> MDMA
Slide 49
When looking at the neurobiological factors that contribute to the etiology of conduct disorder, low levels of this in the CSF correlate with aggression and violence
What is 5-HIAA?
High levels of plasma serotonin (inverse relationship)
Slide 20
According to brain MRI studies, those who use methamphetamine will have a reduction in the volume of this
What is grey matter?
Seen in those with chronic alcohol use as well
Also see decreased activity of the frontal cortex
A score above this threshold on the Clinical Opiate Withdrawal Scale (COWS) is characterized as severe
What is >36?
5-12 -> Mild
13-24 -> Moderate
25-36 -> Moderately severe
Slide 43
This is also known as the "first dose" effect when using cocaine
What is Acute Tachyphylaxis?
Rapid decrease in response during binges, no long-term tolerance
Slide 22
Along with serotonin syndrome, these are the other 4 life threatening effects of MDMA intoxication
BP?
P?
Temp?
Na?
What are Hypertension, Tachycardia, Hyperthermia, Hyponatremia?
Slide 79