MOA
Buprenorphine
What is: Mu opioid receptor (MOR) partial agonist?
This is the street name for LSD
What is: Acid
This is the street name for Ketamine
What is: Special K
This is the street name of Psilocybin
What is: magic mushrooms or shrooms?
This is the street name for MDMA
What is: Ecstasy?
Ketamine
What is: NMDA receptor antagonist?
The length of time LSD psychedelic effects last
What is: > 12 hours
This is the enantiomer of Ketamine that is most potent at blocking NMDA receptors
What is: the S enantiomer (Esketamine)
The length of time psychedelic effects of psilocybin last
What is: 4-6 hours?
Research has shown this mental health condition can improve with exposure to MDMA
What is: PTSD
Psilocybin
What is: 5HT2A receptor agonist?
Research has found these two mental health conditions improve with LSD leading Switzerland to make LSD available for compassionate care
What are:
1) Depression
2) Trauma/PTSD
These are the downstream effects of Ketamine's NMDA antagonism that enhance neuroplasticity
What is:
1) Disinhibits GABAnergic interneurons creating glutamate surge and AMPA receptor upregulation
2) enhances Tyrosine kinase B & mTOR signaling
3) enhances release of BDNF
4) enhances synaptogenesis
Research has shown these three mental health conditions can improve with exposure to Psilocybin
What are:
1) Treatment resistant depression (TRD)
2) Anxiety
3) OCD
Functional MRI studies have identified these two Limbic sites of action of MDMA explaining its therapeutic value for trauma
What are: The amygdala and hippocampus
MDMA inhibits the emotional memory circuits, helping patients relive trauma without being overwhelmed by the emotions
PCP
What is: 5HT2A receptor agonist?
Research has demonstrated LSD can significantly reduce this substance use disorder
What is: Alcohol Use DO
This is the relative bioavailability of Ketamine based on route of administration:
1) IV
2) IM
3) Intranasal
4) Oral
What is:
Intravenous: 100%
Intramuscular: 93%
Intranasal esketamine: 30-50%
Oral: 10-20%
Research has demonstrated these two substance use disorders can improve with exposure to Psilocybin
What are:
1) Alcohol Use DO
2) Tobacco/nicotine dependence
Research has shown this substance use disorder has can improve with exposure to MDMA
What is: Alcohol use Disorder?
MDMA (3)
What are:
1) Blocks & reverses SERT reuptake pump?
2) 5HT2A receptor agonist?
3) Inhibits Tryptophan hydroxylase?
This is the most well-known originator of the research showing LSD has efficacy for reducing certain substance use disorders
Who is: Bill Wilson (founder of Alcoholics Anonymous)
Antidepressant/anti-suicidal effect of Ketamine are modulated by this other neurotransmitter system. Provide one example of an inhibitor and potentiator of ketamine in this interconnected system.
What is: the opiate system
Naltrexone blocks antidepressant effect
Buprenorphine potentiates anti-suicidal effect
This is the chemical Psilocybin is converted into that possess its psychoactive properties
What is: Psilocin?
These are the result of MDMA inhibiting Tryptophan Hydroxylase
What is:
1 reduced synthesis of Serotonin
2) increased synthesis of Cortisol, Oxytocin, Vasopressin, and Dopamine