Prohibition Impacts
What happened in the 1800s that gave rise to drug laws?
Mid 1800s: Chinese workers arrived in California to work on the railroad.
Which amendment to the United States Constitution enacted alcohol prohibition?
The 18th Amendment to the United States Constitution enacted alcohol prohibition.
What is esketamine proposed for the treatment of?
Esketamine is proposed for the treatment of treatment-resistant depression (TRD)
What organization recommended rescheduling marijuana and hemp products under international treaties?
The World Health Organization (WHO) recommended rescheduling marijuana and hemp products under international treaties
What was the impact of alcohol prohibition on per capita alcohol use?
The impact of alcohol prohibition led to a reduction in per capita alcohol use
Name one unintended consequence of alcohol prohibition
One unintended consequence of alcohol prohibition was the significant foregone tax revenue for the government.
Name one adverse event associated with esketamine treatment
One adverse event associated with esketamine treatment is sedation
What are some of the considerations in assessing the risk-benefit balance of esketamine for the treatment of TRD?
Some considerations in assessing the risk-benefit balance of esketamine for the treatment of TRD include the severity of TRD, the inadequacy of existing treatments, and the potential impact on patient outcomes.
Name one success of alcohol prohibition
One success of alcohol prohibition was the reduction in alcohol-related harm, such as liver cirrhosis and alcohol-related deaths
How did alcohol prohibition impact government revenue?
Alcohol prohibition resulted in significant foregone tax revenue for the government.
How often is esketamine proposed for administration in conjunction with an oral antidepressant?
Esketamine is proposed for administration twice a week for an initial 4 weeks in addition to a newly initiated oral antidepressant.
What strategies are proposed to mitigate the risks associated with esketamine treatment?
Strategies proposed to mitigate the risks associated with esketamine treatment include risk evaluation and mitigation strategies (REMS) such as restricted distribution, prescriber training, patient monitoring, and enrollment in a registry.
What lesson can be drawn from the successes and failures of alcohol prohibition for current discussions on drug prohibition?
the importance of weighing potential benefits against social and economic costs.
What major consequence of alcohol prohibition contributed to the rise of organized crime?
The major consequence of alcohol prohibition contributing to the rise of organized crime was the establishment of a black market for alcohol.
Who makes decisions regarding scheduling, rescheduling, and descheduling of drugs under the Controlled Substances Act
Decisions regarding scheduling, rescheduling, and descheduling of drugs under the Controlled Substances Act are made by the Attorney General.
What percentage of patients with major depressive disorder do not respond to first-line treatments, leading to treatment-resistant depression
Approximately 30-40% of patients with major depressive disorder do not respond to first-line treatments, leading to treatment-resistant depression.
What factors contributed to the erosion of public support for alcohol prohibition over time?
Over time, the erosion of public support for alcohol prohibition was influenced by factors such as increased crime rates, corruption, and widespread disrespect for the law.
What alternative strategies to prohibition should policymakers consider based on the lessons learned from alcohol prohibition?
Policymakers should consider less restrictive alternatives to prohibition, such as taxation and regulation, which may achieve similar public health goals with fewer adverse effects.
What are the risks associated with esketamine treatment for treatment-resistant depression?
Risks associated with esketamine treatment for treatment-resistant depression include adverse events such as sedation, dissociation, and increased blood pressure.
Would you approve the FDAs application? Why or why not?
Give your answer