LETs learn
What LET stands for
What is linear energy transfer?
What is false?
What is tumor control probability and normal tissue complication probability?
The EQD2 is a simple way of expressing a biological response relative to what dose per fraction?
What is 2 Gy fractions?
Hyperfractionation is defined as what?
What is delivering 2 or more radiation fractions per day?
Gamma rays and are referred to high or low LET particles.
What is low LET?
What RBE stands for.
What is Relative Biological Effectiveness?
Tpot is defined as the doubling of tumor cells and typically has this unit for time.
What are days?
What is approximately 6 hours? (or about a day for the spinal cord?)
What is higher?
Ex: EORTC 22971 compares 80.5Gy in 70 fx vs. 70Gy in 35 fx
While gamma rays release about 0.3 keV/micron, these particles release about 100 keV/micron.
What are alpha particles?
For a given particle, the RBE can depend on the dose and this property of the particle.
What is the energy?
The classical four 'R's of radiobiology.
What are repair of DNA damage, redistribution of cells in the cell cycle, repopulation, and reoxygenation of hypoxic tumor areas?
The Lea-Catcheside factor 'g' is used to accommodate for the dose per fraction effect if sublethal recovery is not complete. True or false?
What is true?
This fictional dinosaur was awakened from the depths of the Pacific ocean from a nuclear detonation.
What is Godzilla?
True or false: neutrons have lower LET than alpha-particles?
(Depends on the neutron energy)
When is 'Overkill'?
What the 'n' stands for in the BED equation.
What are the total number of fractions, n?
For most tumor types and for early endpoints, the biological effect of a specific dose-fractionation will (increase/decrease) if overall treatment time is increased.
What is 'decrease'?
(biological effect decreases if overall treatment time is increased)
The hype of hypofractionation greatly facilitated due to these technologies that significantly reduce the risk of toxicities.
What are image guidance and intensity modulation?
The field of dosimetry related to effects at the cellular dimensions is known as this:
What is microdosimetry?
What is about 1.1?
alpha/beta
value (estimate) for an early reaction of skin.
What is 9-12 Gy?
Errors in total dose delivery can be 'corrected' for by using Joiners' formula of
D= P - E & d = Pp - Ee / (P - E).
What does P and p stand for?
P is the total planned dose, and p is the planned dose per fraction.
Walter White (Breaking Bad) was treated for this type of cancer.
What is lung cancer?