Me and my blue genes
What's in a name?
There's nothing you can know that isn't known
It was Colonel Mustard in the Study
100
Down's and up - These patients have increased risk of Alzheimer Disease due to encoding of this protein on chromosome 21
what is amyloid precursor protein (APP)?
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100
Seen here, this South African psychiatrist is one of the fathers of behaviorism, perhaps most famous for reciprocal inhibition and systematic desensitization 
Who is Joseph Wolpe?
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reciprocal inhibition: inhibition of fear/anxiety by a feeling or response that is incompatible with fear/anxiety (i.e. assertiveness training)
systematic desensitization: exposing client to progressively stronger anxiety-producing stimuli until anxiety resolves
100
Named after a Greek mythology sculptor who fell in love with his own sculpture, this occurs when higher expectations lead to increased performance
What is the Pygmalion effect (aka observer-expectancy bias)
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100
The MAOI used in level 4 of the STAR*D study along with mirtazapine venlafaxine er combination
What is tranylcypromine?
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Interventions
Participants progressed through four different levels of treatment.
- Step 1: All participants received flexible-dose citalopram. If in remission, enter 12-month naturalistic follow up. If no remission, proceed to step 2.
- Step 2: 3 augmentation strategies (citalopram + bupropion; citalopram + buspirone; citalopram + CBT) and 4 switch strategies (buproprion, sertraline, venlafaxine, CBT). If in remission, enter 12-month naturalistic follow up. If no remission, proceed to step 3.
- Step 3: 2 augmentation strategies (lithium or triiodothyronine [T3]) and 2 switch strategies (nortriptyline, mirtazapine). If in remission, enter 12-month naturalistic follow up. If no remission, proceed to step 4.
- Step 4: randomized to treatment with either tranylcypromine or combination venlafaxine XR and mirtazapine.
Outcomes
Comparisons are level 1 vs. level 2 vs. level 3 vs. level 4.
Primary Outcome
Depression remission by QIDS-SR16 score
Step 1: 36.8% (higher remission rate than those in step 2; P<0.001)
Step 2: 30.6% (higher remission rate than those in step 3; P<0.001)
Step 3: 13.7%
Step 4: 13%
200
When methylated, these musical-sounding proteinaceous structures are transcriptionally inactive
What are histones?
200
The 1950-60s cognitive psychology revolution was ignited by this New Yorker, who developed what is considered the first form of CBT, sorry Beck
Who is Albert Ellis?
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Developed rational emotive behavior therapy (REBT) - irrational core beliefs cause disturbance in emotion which leads to actions by the client; these core beliefs are challenged and changed
200
Glycine may be a nonessential amino acid, but it acts as this at the NMDA receptor
What is an obligate coagonist?
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obligate = necessary to bind
co-agonist = binds with d-serine and glutamate for NMDA receptor activation
200
Incorrectly rejecting the null when it's actually true, or derived from the Phoenician symbol for 'leader'
What is a type I error (alpha)?
300
You may mistake this genetic syndrome as descended from Yahweh, rather than from epigenetic imprinting
What is Angelman Syndrome?
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imprinting = gene expression is dependent on which parent passed down the mutant gene
Angelman = paternal imprinting (father's gene is normally silent); lof on maternal chromosome 15)
Prader-Willi = maternal impritning (mom's gene is normally silent); del on dad's chromosome 15
300
This Swiss mister came up with concepts like the collective unconscious & archetypes
Who is Carl Jung?
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Concepts:
-founder of analytical psychology
-individuation: the process of differentiation of the self out of each individual's conscious and unconscious elements (the main task of human development)
-synchronicity: events are meaningful coincidences if they occur with no causal relationship yet seem to be meaningfully related
-archetypes: universal symbols/images from the collective unconscious; psychological instinct (innate unspecific knowledge)
-collective unconscious: structures of the unconscious mind which are shared among beings of the same species
-introversion and extraversion
300
The Nathan's hot dog eating contest was won with ease this year after a craniopharyngioma disrupted this section of the winner's hypothalamus
What is ventromedial?
300
This is not a new dancing style but a named study that found adding antidepressants to mood stabilizers didn't improve bipolar depressive symptoms better
What is the STEP-BD?
400
When Michael Scott described his vasectomies to Jan, he wasn't referring to these differences in a nucleotide that occur normally throughout a person's genome
What are SNPs (single nucleotide polymorphisms)?
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Genome Wide Association Studies: look for common SNPs and variants to identify genes influencing complex disorders
400
A former theologian, this American pioneered humanistic psychologist with his client-centered therapy
Who is Carl Rogers?
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Key concepts: client-centered therapy, unconditional positive regard, self-actualization, "the fully functioning person"
400
Don Draper knows this nicotinic acetylcholine receptor, the target of varenicline, lights up his NA and VTA with each pack of his Lucky Strikes
What is ɑ4β2 ?
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400
A RCT involving antipsychotics showed that 8% of patients in the metformin group developed T2DM while 18% in the treatment as usual group developed T2DM. You'd say the number needed to treat for metformin is this
500
You wouldn't look forward to this genetic phenomenon seen in many trinucleotide repeating disorders, such as Huntington's disease
What is anticipation?
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anticipation = increased severity or earlier onset of disease with subsequent generations
Huntington's = CAG
Myotonic dystrophy = CTG
Fragile X syndrome – CGG
500
Attachment styles were defined in strange research by this psychologist
Who is Mary Ainsworth?
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500
Named after an early 20th century dynamic duo, this states that there is an optimal level of physiologic arousal or anxiety for task performance
What is the Yerkes–Dodson law?
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500
Originally described in research from a Western Electric plant in Illinois, this is when individuals modify an aspect of their behavior in response to awareness of being observed
What is the Hawthorne effect?