Drug Knowledge
This monoclonal antibody is represented by the “R” in R-CHOP.
What is Rituximab?
These two medications are commonly administered before Rituximab to reduce infusion reactions.
What are acetaminophen and diphenhydramine?
Patients should report a fever of this temperature or higher immediately.
What is 100.4°F / 38°C?
Rapid destruction of cancer cells after treatment causes this oncologic emergency.
What is Tumor Lysis Syndrome?
Before administering chemotherapy through a peripheral IV, the nurse should verify this.
What is blood return / patent IV access?
This chemotherapy drug commonly causes peripheral neuropathy.
What is Vincristine?
This is the first nursing action when a patient develops wheezing and hypotension during a Rituximab infusion.
What is stop the infusion immediately?
This medication should usually be taken in the morning with food.
What is Prednisone?
This R-CHOP medication is most associated with cardiomyopathy.
What is Doxorubicin?
Burning at the IV site with no blood return during Doxorubicin administration suggests this complication.
What is extravasation?
This anthracycline is associated with cardiotoxicity and causes red-orange urine after treatment.
What is Doxorubicin?
This type of chemotherapy agent can cause severe tissue damage if extravasation occurs.
What is a vesicant?
Patients receiving Cyclophosphamide should be encouraged to do this to reduce bladder toxicity.
What is increase hydration / fluids?
This electrolyte abnormality is commonly seen with Tumor Lysis Syndrome.
What is hyperkalemia?
The most important assessment before administering Vincristine focuses on this body system.
What is the neurologic system?
This alkylating agent can cause hemorrhagic cystitis.
What is Cyclophosphamide?
After an infusion reaction resolves, Rituximab is generally restarted this way.
What is at a slower rate per protocol/order?
Patients with severe neutropenia should avoid eating these foods.
What are raw or undercooked foods?
This medication is commonly prescribed to help prevent Tumor Lysis Syndrome.
What is Allopurinol? (Rasburicase may be used for high-risk patients.)
A patient develops rigors, wheezing, hypotension, and oxygen saturation of 88% during their first Rituximab infusion. What is the priority nursing intervention?
What is stop the infusion, assess ABCs, initiate emergency management, and notify the provider?
This medication should never be administered intrathecally.
What is Vincristine?
This antidote may be used following anthracycline extravasation.
What is Dexrazoxane?
This laboratory value is the most important indicator of neutropenia severity.
What is Absolute Neutrophil Count / ANC?
A neutropenic patient with a fever should be treated as having this medical emergency.
What is febrile neutropenia / neutropenic fever?
Place these severe Rituximab reaction actions in order: maintain IV access, assess ABCs, stop infusion, notify provider/activate emergency response, administer emergency meds, document/restart only if appropriate.
What is: 1) stop infusion, 2) maintain IV access, 3) assess ABCs/vitals, 4) notify provider/activate emergency response, 5) administer emergency meds per protocol, 6) document/monitor/restart only if ordered?