What are β-adrenergic receptor, muscarinic acetylcholine receptor, metabotropic glutamate receptors, and receptors for odorants in the olfactory system?
100
Vitamin D produces its effects by acting on these receptors.
What are intracellular steroid receptors?
100
Mediates activation of adenylyl cyclase, synthesis of cAMP, and activation of L-type Ca2+ channels.
What are functions of Gs?
100
Channels composed of three subunits, a pore-forming alpha subunit and two beta regulatory subunits.
What are Na+ channels
100
Membrane proteins that control influx of essential nutrients and ions and efflux of cellular waste, environmental toxins, drugs, and other xenobiotics.
What are transporters?
200
Magnitude of the response, selectivity, and pharmacologic actions.
What are three attributes of receptors?
200
Targets for anesthetics such as lidocaine and tetracaine.
What are voltage-activated Na+ channels?
200
Angiogenesis
What effects are produced by vascular endothelial growth factor (VEGF) in a tumor?
200
Are responsible for hereditary as well as acquired (drug-induced) long QT syndrome and are primary targets of many anti-arrhythmic drugs that prolong repolarization.
What are cardiac KCNH2 channel?
200
Primary active transporters, use ATP hydrolysis to actively pump their substrates across membranes.
What is ATP binding cassette?
300
Drugs acting on these receptors have slow onset of action and produce long-term effects.
What are intracellular receptors?
300
These steroids will not relieve acute symptoms of bronchial asthma.
What are glucocorticoids?
300
Increased phospholipase C, increased IP3, diacylglycerol, and cytoplasmic Ca2+
What are four molecules are activated by Gq?
300
The drug Tolbutamide inhibits these ion channels.
What are K+(ATP) channels?
300
Play role in selective absorption and elimination of endogenous substances and drugs.
What does a transporter do?
400
When stimulated, they act primarily by altering flow of ions through plasma membranes.
How do ligand-gated ion channels act?
400
These agents are effective vasodilators and are widely used to treat angina, cardiac arrhythmias, and hypertension.
What are the uses of nifedipine, diltiazem, and verapamil?
400
Increased adenylyl cyclase, increased cAMP, and increased activation of L-type Ca 2+ channels
Which three signaling molecules are activated by Gs
400
Serotonin receptor modulators affects these channels
What are sodium channels?
400
Serve as protective barriers, example: blood-brain barrier.
What is P-glycoprotein
500
Mediate signaling by hormones such as insulin, epidermal growth factors (EGF), and platelet-derived growth factors (PDGF).
What are enzyme-linked receptors?
500
It opens K+ channels and can be used in the treatment of epilepsy.
What is retigabine?
500
Positive inotropic and chronotropic effects of beta receptors.
What effects does Cyclic AMP mediated in heart?
500
Antiepileptic drugs use these channels to produce their effects.
What are Cl- channels
500
Overexpressed in tumor cells after exposure to cytotoxic anticancer agents and pumps out the anticancer drugs, rendering cells resistant to their cytotoxic effects