Surfactant Agents
What is the composition of surfactant?
90% lipids & 10% proteins
Which medication prevents bronchospasm by inhibiting mast cell degranulation?
Cromolyn Sodium
What is the general indication for clinical use of nonsteroidal antiasthma agents?
What is prophylactic management of mild persistent asthma.
The physician would like your recommendation for a drug to give your CF patient with chronic Pseudomonas infections. What would be the best recommendation?
What is Tobramycin
This type of cell is a connective tissue cell that contains heparin and histamine.
What are mast cells.
Which of the following happens as the surface tension of the liquid lining of the alveolus increases?
a. More pulmonary blood flow perfuses the alveoli
b. It becomes more difficult for the alveolus to inflate
c. Airway resistance decreases
d. More type I cells are produced
b. It becomes more difficult for the alveolus to inflate
What is the general indication for clinical use of nonsteroidal antiasthma agents?
Prophylactic management of mild persistent asthma
How is Cromolyn Sodium is effective in preventing bronchospasm?
What is by inhibiting mast cell degranulation (mast cell stabilization).
What is the approved dose of pentamidine by aerosol for prevention of PCP?
What is 300 mg once every 4 weeks.
True or False. Nonsteroidal antiasthma drugs are rescue drugs.
False. They are maintenance drugs.
Which surfactant protein is important in the regulation of surfactant metabolism?
Surfactant Protein A (SP-A)
What is the only antileukotriene agent currently approved for use in patients younger than 5 years of age?
Singulair
What is the most commonly reported side effect of cromolyn sodium?
What is nasal congestion.
What is the mode of action of pentamidine?
Unknown
True or False.
Detergent is another name for surface-active agents.
True
Lack of which surfactant protein has been shown to lead to emphysema?
Surfactant Protein D (SP-D)
What is the trade name for ribavirin?
Virazole
Leukotrienes exhibit which of the following effects? (Choose all that apply)
1. Increased mucus secretion
2. Increase ciliary action
3. Increased airway edema
4. Bronchoconstriction
5. Recruitment of antiinflammatory cells into airways
What is 1, 3, and 4
An 8-year-old patient is brought to the pediatrician’s office with the complaint of uncomplicated flulike symptoms for 1 day. The pediatrician asks you to suggest an inhaled antiinfective. Which medication is the most appropriate at this time?
Zanamivir
Which medication is available as a 4-mg packet of granules?
What is Monteleukast (Singulair)
Beractant (Survanta) is from which animal?
Cow
What is the name of the nebulizer that is used to aerosolize ribavirin?
Small Particle Aerosol Generator (SPAG Unit)
Which of the following are antileukotrienes (select all that apply): 1. Zafirlukast 2. Zileuton 3. Cromolyn sodium 4. Montelukast 5. Nedocromil sodium
What is 1, 2, and 4
Precautionary measures that are suggested when administering pentamidine to reduce the risk of both drug exposure and tuberculosis (TB) infection include (select all that apply):
1. Use a nebulizer system with one-way valves and expiratory filter.
2. Administer aerosol in a negative-pressure room.
3. Do not expose pregnant women and nursing mothers to the drug.
4. Use barrier protection.
5. Stop nebulization if the patient takes the mouthpiece out of the mouth.
What is 1, 2, 3, 4, and 5
This is the only antileukotriene agent that is currently approved for use in patients younger than 5 years of age.
What is singulair.