100
What are Heinz bodies
large inclusion bodies (granules) in the RBCs when stained with crystal violet; often seen in the setting of an enzyme (G6PD) deficiency, drug-induced hemolysis, or unstable hemoglobin disease.
Who was our patient in the CML case?
Anthony Cross
What is the first step in primary hemostasis?
Vasoconstriction by endothelins
Proteins C and S inactivate which factors?
V and VIII
I think that[his win] would qualify as not smart, but genius....and a very stable genius at that!
Donald Trump
A translocation between which two chromosomes creates the Philidelphia chromosome?
9/22
Describe Bernard Soulier syndrome
A genetic deficiency in GPIB receptors. Platelet adhesion is impaired
A genetic GPIIB/IIIA deficiency. Platelet aggregation is impaired
What does PT stand for and what does it measure
Prothrombin time, the intrinsic pathways time to clot
Will you shut up, man?
Joe Biden
List the contents of dense granules
ADP, Ca2+, Serotonin
Describe the MOA of warfarin
Inhibits Vitamin K epoxide reductase=> Vitamin K cannot be activated and used by Factors II, VII, IX, X, and Protein C and S
What are the three components of Virchows Triad
Stasis of blood, vascular endothelial injury, hypercoagulability
Describe the TNM staging system
T- tumor size and depth
N- spread to regional lymph nodes
M- metastasis
He's warm, he's cuddly, loyal, enthusiastic; you just have to keep him in on a tight leash -- every once in a while he goes charging off and gets himself into trouble.
Barack Obama
CML can progress to which two acute leukemias
Acute myelogenous leukemia (66%)
Acute lymphoblastic anemia (33%)
List Lab Studies for secondary hemostasis?
Prothrombin time, Patrial thromboplastin time
Describe the ristocetin test and its involvement with vWB disease
Ristocetin induces agglutination via vWB factor and GPIB, so a lack of vWB would produce a lack of/impaired agglutination.
What do you call the products of Fibrin breakdown, and which one, in particular, is the best indicator for the presence of clots?
Fibrin Degradation products
D-dimers
In another sense, I tested positively toward negative, right? So no. I tested perfectly this morning, meaning I tested negative. But that's a way of saying it. Positively toward the negative.
Donald Trump
What is a neoplastic proliferation of mature myeloid cells-especially granulocytes and their precursors? Basophils are significantly increased.
Chronic myeloid leukemia
In alpha thalassemia, how does a four-gene deletion affect the pregnancy, and what precipitates on a Hgb electrophoresis?
Hydrops fetalis and Hgb Barts( gamma tetramers)
What is the cause of Hemophilia A and how would the PT/ PTT present?
F VIII deficiency
Increased PTT
Normal PT
Which normocytic anemia presents with extravascular hemolysis and is diagnosed with an osmotic fragility test? It can be characterized by a lack of stabilizing membrane proteins
Hereditary Spherocytosis
There's an old saying in Tennessee — I know it's in Texas, probably in Tennessee — that says, fool me once, shame on — shame on you. Fool me — you can't get fooled again.
George W Bush