Rheumatology

Pathophysiology

100

These crystals build up in gout

Uric Acid

200

This imbalance leads to osteoporosis

Bone resorption and remodeling

300

These two antibodies are the best-known autoantibodies in rheumatoid arthritis

RF & ACPA

400

This key component of synovial fluid is diminished in osteoarthritis

Hyaluronic acid

500

This cytokine is central in the pathogenesis of psoriatic arthritis

IL-23

Symptoms & Signs

100

One of the hallmarks of this condition is morning stiffness

Rheumatoid Arthritis

200

This condition is associated with symmetrical pain & stiffness in the shoulder, neck & hip girdle 

Polymyalgia Rheumatica

300

This rash is commonly associated with SLE

Malar (Butterfly)

400

This pattern is the most common psoriatic arthritis presention

Asymmetic oligoarticular (<5 joints)

500

Heliotrope rash is the first sign of this condition

Dermatomyositosis

Diagnosis

100

This DEXA T-score indicates osteoporosis

-2.5 SD or below

200

This imaging technique is preferred for assessing joint damage in osteoarthritis

MRI

300

This condition is diagnosed by exclusion as well as response to treatment

Polymyalgia Rheumatica

400

This condition results in low serum calcium, low serum phosphate, raised ALP and raised PTH

Osteomalacia

500

This blood test is most associated with a poor prognosis in rheumatoid arthritis

anti-CCP

Management

100

This should typically be prescribed alongside longterm NSAIDS

Omeprazole

200

This DMARD is most commonly used as initial management for Rheumatoid Arthritis

Methotrexate

300

This medication is first-line for acute gout attacks

NSAIDs

400

Poor kidney function is an indication for which fracture prevention medication 

Denosumab

500

This advice should be given to a male patient with chron's disease controlled with methotrexate looking to start a family

Stop treatment for at least 6 months before attempting to conceive

Epidemiology

100

This modifiable risk factor is most strongly associasted with rheumatoid arthritis

Smoking

200

Around 50% of post-menopausal women will experience this at some point

Osteoporotic Fracture

300

This condition most commonly affects males aged 20-30

Ankylosing Spondylitis

400

The age range where onset of psoriatic arthritis is usually seen

30s-40s

500

This explains the gender difference in age of onset of gout

Renal uric acid clearance due to oestrogen