What are the tests that should be ordered in lupus proliferative nephritis and correlates with disease activity
Anti-DsDNA abs, complement level (C3,C4)
200
Describe peripheral MSK involvement in patients with ankylosing spondylitis (type of joint...): Arthritis
large, oligo, asymmetric + enthesitis
200
What are two blood tests used in diagnosis with relatively good sensitivity / specifity?
RF (70% sens), anti-CCP (60 sens, 95 speci)
200
What are the indications for starting urate-lowering therapy?
If 2 or more attacks of gouty attacks or if tophi present
200
Which location has the highest yield to biopsy for diagnosis of polyarteritis nodosa?
involved skin, symptomatic muscle or sural nerve
300
3- What are the classic antibodies found in drug induced lupus?
Anti-ssDNA abs, antihistone abs, ANA
300
Sacroiliitis is positive in only 40% of ankylosing spondylitis even 10 years later after diagnosis. What is preferred alternative testing?
MRI
300
Describe 3 radiologic findings in OA? and what is their relation to disease activity?
joint-space narrowing, osteophytes, subchondral sclerosis, bony cyst formation, and eburnation (deformation of joint surface).
Radiographic severity correlates poorly with severity of symptoms.
300
How do the calcium pyrophosphate crystals look under microscope?
Positively birefringent rhomboid shape crystal
300
Which one test that if positive in a patient with classic presentation of granulomatosis with polyangiitis presentation, would be enough for diagnosis?
C-ANCA antibodies would be sufficient and no need for biopsy if classic presentation
400
4- In patients with + antiphospholipids abs, Hx of late pregnancy loss, what is indicated preventive treatment during subsequent pregnancy?
Low dose aspirin and heparin
400
What is first line treatment for ankylosing spondylitis?
NSAIDs, nonbiologic DMARDs has no role in axial, TNF inhibitors beneficial in axial and peripheral involvement
400
What is gold standard treatment of RA?
Methotrexate
400
What other preventive treatment is indicated when initiating urate lowering agent? and for how long?
Colchicine for minimal of six months
400
What is treatment for microscopic polyangiitis?
High-dose corticosteroid therapy accompanied by a 3- to 6-month course of cyclophosphamide
500
5- Which blood test is good predictive of neonatal lupus erythematous in pregnant females with SLE?
Maternal anti-Ro/SSA, anti-La/SSb
500
Which test is indicated in patients with sudden onset severe psoriatic arthritis
HIV testing
500
Decision for joint replacement is made in OA based on what?
Symptoms and quality of life rather than radiologic findings
500
40 YO M presenting wiht 1st MTP joint swelling and severe pain, what is next step?
Empirical treatment, no need for joint aspiration
500
Patient with rash, and mononeuritis multiplex diagnosed with PAN, which additional testing is indicated to rule out underlying etiology for PAN?
Hepatitis B work up, 50% of PAN cases occur in the setting of recently acquired hepatitis B infection