Acronyms
RSV
Respiratory Syncytial Virus
Which cell type leads to antibody creation?
B-Cells lead to antibody creation, which is the connection to vaccines and MAbs
What is used to manufacture MAbs?
living cells
What is the leading cause of lower respiratory tract infections in infants?
RSV
What is the non-branded name for Beyfortus?
nirsevimab
MAb
monoclonal antibody
Microorganisms that cause infection
pathogens
Is protection slow or rapid?
Is RSV circulation annual or seasonal?
Nirsevimab does not prevent RSV in the nose. What does it do?
It stops RSV progression to the lungs, which is where serious lower respiratory infections occur.
MOA
mechanism of action
Any substance recognized which induces an immune response
antigen
True of False: All vaccinations are immunizations and all immunizations are vaccinations?
FALSE - It's important to refer to MAbs as immunizations and not vaccinations
Which protein fuses virus to a cell?
pre-fusion F protein
Nirsevimab provides protection for about ____ months, which is about the typical length of what?
5 months + RSV season
LRTI
Lower respiratory tract infection
2 main types of lymphocytes
T-Cells (T-Lymphocytes) and B-Cells (B-T-Lymphocytes)
_______ provide active immunity whereas MAbs provide _____ immunity.
Vaccines + Passive
RSV infection starts in the _____ and progresses to the _____.
Nose + Lungs
Which of the following statements is true of Nirsevimab?
1. It targets G protein
2. It stops progression of RSV
3. It prevents RSV
4. It targets pre-fusion F protein
2 + 4: Nirsevimab targets the pre-fusion F protein to stop the progression of RSV.
VFC
Vaccines for Children
Define passive immunity
When the body receives antibodies rather than makes them. It can occur naturally from pregnant person to fetus or through provision of antibody products like IGGs and MAbs.
Typical length of time for protection with a standard MAb vs. a longer-acting MAb?
1 month vs. 5 months
Infants under 12 months of age are more likely to develop severe RSV disease than adults or toddlers/children. This is partly because their immune system is ___ ______.
less developed - and their lungs contain very small and fragile airways that can easily be obstructed by inflammation and fluid build-up.
When was Beyfortus approved by the FDA in the United States?
July 17th, 2023