1
Is there currently a RSV vaccine?
Yes
True or False: RSV symptoms can vary based greatly based on age and past medical history
True
In what animal was RSV originally identified in
a. Chimpanzee
b. Dog
c. Rat
d. Frog
Chimpanzees
True or False: You can only get RSV as a child.
False, all age groups could be affected
Can someone have RSV multiple times?
Yes, similar to the flu there are different strains of RSV
Is RSV a DNA or RNA virus?
An RNA virus
How does RSV spread?
Through droplets (Coughing, sneezing, surviving on surfaces such as desks)
Name a patient population that is most affected by RSV?
Children under 2, older adults, immunocompromised patients
What year was the first RSV vaccine approved for use in the United States?
a. 2007
b. 2012
c. 2019
d. 2023
2023 (but SYNAGIS developed a monoclonal antibody injection in 1998 used to prevent severe RSV disease in high-risk infants through monthly injections during RSV season)
What does RSV stand for?
Respiratory syncytial virus
In what season is RSV most prevalent?
Winter
Name two RSV symptoms.
Examples include: Fever, sore throat, nasal congestion, dry cough, decreased appetite, wheezing, apnea, rhinitis
By age 2, what percentage of children have had RSV?
a. ~20%
b. ~50%
c. ~80%
d. ~100%
Nearly 100% of all children
Why are antibiotics ineffective against RSV?
RSV is a virus not a bacteria
How many children in the world under the age of 5 die from RSV every year (in thousands)
a. 1
b. 10
c. 50
d. 100
100
Name one group of people that the RSV vaccine is available for.
Pregnant people, individuals over the age of 60, immunocompromised adults
In what decade was the RSV genome sequenced?
a. 1960s
b. 1980s
c. 2000s
1980s
For minor cases of RSV name one treatment.
Rest, hydration, OTC medication, humidity
What is the best way to reduce the spread of RSV?
Frequent handwashing and covering coughs/sneezes.
How is RSV diagnosed in a clinical setting? (hint think how other respiratory diseases are diagnosed)
Nasal swab
What is the recommended method for protecting infants and young children from severe RSV?
Long-acting monoclonal antibodies (mABs) such as Nirsevimab or Beyfortus. They deliver pre-made antibodies that block the RSV virus from entering cells.
Getting vaccinated between 32 and 36 weeks of pregnancy provides protection from severe RSV for the first 6 months of a infants life.
What is the number one cause of respiratory failure in children?
Bronchiolitis caused by RSV
What protein does the Moderna's mResvia vaccine mimic?
The pre-F protein
Why are children under 1 year old are at higher risk for severe RSV?
Their immune systems are still developing and their airways are very small (can be easily blocked by mucus)
What is one of the two RSV vaccines approved by the FDA that are not mRNA vaccines?
Arexvy or Abrysvo