Proteins in Fe metabolism
Protein to transport iron in circulation
What is transferrin (lactoferrin)
Organ to produce hepcidin
What is liver
Decreased alpha-globin chain synthesis due to gene deletion
What is hemoglobinopathy (alpha-thalassemia)
mg of Fe per ml of blood
What is 0.5
It is the acronym for IRP
What is Iron Regulatory Protein
Protein to store iron
What is ferritin (hemosiderin)
Receptor for hepcidin
What is ferroportin
Low serum Fe with normal/high ferritin
What is ACD
Hepcidin is elevated in this anemia
What is ACD
It is a stem loop structure in mRNA
What is IRE (Iron Responsive Element)
Membrane protein to move iron from circulation into cells
What is transferrin receptor
This signal induces hepcidin release
What is increased Fe / infection / inflammation
Low serum Fe with low ferritin
What is IDA
A mutation of this gene causes SA
What is ALA-S2
It contains a 5'-IRE
What is ferritin/ALA-S2 mRNA
Protein to move iron out of certain types of cells into circulation
What is ferroportin
This signal inhibits hepcidin release
What is decreased Fe level / hypoxia (high erythroid demand)
Pappenheimer bodies observed in circulating RBCs
What is SA
Concave, spoon-shaped nails
What is koilonychia
High iron levels results in translation of this mRNA
What is ferritin mRNA (ALA-S2)
Protein to move iron from GI tract into enterocytes
What is DMT-1
This molecule produced by macrophages induces hepcidin release during infection
What is IL-6
Lead chelator recommended for treatment
What is SA
Its release from neutrophils is induced by IL-1
What is lactoferrin
Low iron levels results in translation of this mRNA
What is TfR mRNA (DMT-1)