What is it?
What is it not?
Check all my labs
Am I gonna die?
Feb 14th
100
In the January 2024, Vol 109, Number 1 article, sarcoidosis was defined as this.
Multisystem granulamatous inflammatory disease that can affect any organ
100
Sarcoidosis can affect the central nervous system. The article listed several examples of infectious and non-infectious causes that need to be in the differential diagnosis. Name one differential for each.
Infection: TB, Brucella, Fungi, Amoeba, Toxoplasmosis, Schistosomiasis, Varicella, HSV
Non-infectious: IgG4 disease, CVID, Histocytosis, Amyloid, Rheumatoid noduels, cholesterol granuloma, heavy metals, toxins, drugs. etc.
100
Consensus guidelines recommend diagnostic approach including radiographic findings, biopsy-proven noncaseating granuloma, exclusion of other etiologies, and this.
Involvement of more than one organ system.
100
This percentage of people experience spontaneous remission after 2 years.
Approximately 50%
100
Coincidentally, Valentine's day this year is also this religious holiday.
First day of Lent
200
The etiology of sarcoidosis is unknown, but the estimated heritability is in this range.
60-70% based on heterogenous studies across populations.
200
Sarcoidosis can affect any organ, which makes this particular differential diagnosis one that needs to be considered. It can be a pain in the rear.
Chron's disease
200
This is a common finding on radiographic imaging that raise the question of sarcoidosis.
Bilateral hilar lymphadenopathy.
200
In the US the overall age-adjusted mortality rate for sarcoidosis is this
3.1%
200
Cupid is the roman god of love. This is the greek god of love.
Eros
300
This diagram explains this concept of epidemiology
8-11/100K annual incidence, 60-100/100K annual prevalence.
300
Sarcoidosis can affect the skin. Please list 2 other diagnoses that look similar to this.
Psoriasis
Lichenoid dermatitis
Discoid lupus
Deep sub-q nodules
Etc...
300
This is the term used to describe when a clear piece of glass or plastic is applied over a cutaneous lesion to look for blanchability.
Diascopy - used to see if a lesion is vascular vs non-vascular. Sarcoidosis lesions are yellow orange on diascopy.
300
The likelihood of progression of sarcoidosis is 20% after this age
50 yrs old
300
How much does a Hershey kiss weigh?
About 0.2 oz (5.6g)
400
These two populations are at increased risk of developing sarcoidosis.
Women (twice as likely as men)
Black people
Note: avg age of diagnosis is 44-56 y/o. Rare in kids.
400
Image is classic for this disease.
Tuberculosis (caseating granuloma)
400
This syndrome is pathognomonic for sarcoidsis. It is characterized by bluish-red or violaceous nodules and plaques that typically appear over the nose, cheeks, and ears. Can cause disfigurement of nose, nasal obstruction, and sinus/pulmonary complications.
Lupus pernio
400
Patient's with no symptoms or mild disease should be monitored and do not require treatment. Symptomatic patients or patients with higher stage disease on testing should start this treatment first line.
Oral corticosteroids (0.5-1 mg/kg/day)
Reassess PFT and chest imaging after 1-3 months of tx.
Wean slowly over 12 months is responsive to treatment.
400
Boston pharmacist Oliver Chase invented this Valentine's day staple in 1847.
Conversation hearts. Invented a lozenge cutter that was soon used exclusively for candy after Chase founded the New England Confectionery Company (later known as NECCO). Then, in 1866, conversation hearts were officially born once his brother, Daniel Chase, discovered a way to stamp words directly onto the candies with red vegetable dye.
500
The leading theories as to the cause of sarcoidosis is that a genetically susceptible person is exposed to an antigen, which sets off an inflammatory response. These were two bacteria mentioned in the article
Mycobacterium
Propionibacterium acnes (P. acnes)
500
This can be caused by cardiac sarcoidosis
RBBB
Note: it can also cause 2nd and 3rd degree blocks as well dysrhythmias.
500
Lofgren syndrome has a more favorable prognosis and is pathognomonic for sarcoidosis. It has these 5 features associated with it (name 3)
Erythema nodosum
Uveitis
Bilateral hilar lymphadenopathy
Polyarthritis
Fever
500
Second line agents if patient does not response to first line agent, include these medications.
Methotrexate 2nd line
TNF alpha-inhibitor (Infliximab) 3rd line
Bonus: lung transplant in severe disease
500
These were the two Valentine's day box themes my kids designed for school this year.
