Immunology
CD8 cells are also known by this name.
Cytotoxic T cell.
A pre-metabolite of 6-mercaptopurine, a purine analogue.
Azothioprine
This type of rejection occurs after months to years.
Chronic
This blood group has the longest wait time on the kidney transplant wait-list
B
Most common cancer following transplant.
Skin (squamous)
MHC class 1 molecules are found on this type of cell.
All nucleated cells
This polyclonal antibody against T-cell antigens is produced in rabbits.
Thymoglobulin
This is the treatment for hyperacute rejection.
re-transplantation
These are the three most critical HLA alleles in the setting of kidney transplant. (name 2 of 3)
HLA-A, -B, -DR
Diarrhea and GI upset are the most common reasons for discontinuation of this anti-metabolite.
Mycophenolate mofetil
MHC class 2 molecules activate this type of cell.
CD4 or T helper cells.
This macrolide antibiotic binds FKBP, inhibiting the mTOR pathway.
Sirolimus or Everolimus
ABO incompatibility leads to hyperacute rejection and this type of hypersensitivity reaction.
Type II
These are the two criteria to be placed on deceased donor transplant list.
GFR below 20
Dialysis
This calcineurin inhibitor has been known to cause gingival hyperplasia.
Cyclosporine
Name 2 things that will increase the percent panel reactive antibody (PRA).
Prior transfusion
Pregnancy
Previous transplant
This drug binds cyclophilin, which subsequently binds calcineurin, inhibiting T cell phosphatase activity.
Cyclosporine
This type of rejection is mediated by T-cell reaction to Donor antigens.
Acute rejection (1 week to a couple of months)
The number of days post kidney transplant that survival is equal between those transplanted and those on the wait list.
244
This agent was recently withdrawn for its side effects of cytokine release syndrome and severe pulmonary edema.
Muromonab-CD3 (OKT3)
This interleukin causes maturation of cytotoxic T cells.
IL-2
This monoclonal antibody binds IL-2 receptor on T cells inhibiting activation, without causing cell lysis.
Basiliximab
These are the 5 absolute contraindications to transplantation. (name 4)
Active substance abuse
Uncontrolled psychosis
Active malignancy
Active infection
Chronic illness with less than 1 year life expectancy
This mTOR inhibitor can lead to interstitial lung disease.
Sirolimus