Definitions
Seizure Classification
Pharmacotherapy
Monitoring & ADRs
Miscellaneous
100
The clinical manifestation of an abnormal and excessive excitation and synchronous neuronal activity in the brain
What is a seizure?
100

This seizure type has no postical state

What is an absence seizure?

100
What prodrug is metabolized to phenobarbital?
What is primidone?
100

Potent CYP 3A4 inducer; autoinduction; rare hepatotoxicity

What is carbamazepine (Tegretal)?

100
Average duration of a typical seizure
What is 1-2 minutes?
200
Two or more recurrent, unprovoked seizures
What is epilepsy?
200

Unaware of environment; automatisms and aura common

What is complex partial seizure? 

200
AED most likely to cause hyponatremia
What is oxcarbazepine (Trileptal)?
200

Has Black Box Warning for Stevens-Johnson Syndrome (SJS)

What is lamotrigine (Lamictal)?

200

Bupropion, tramadol, imipenem, alcohol

What are seizure precipitants?

300
Perceptual disturbance that occurs prior to seizure onset; "premonition"
What is aura?
300

Staring and eye fluttering common; multiple seizures per day

What is an absence seizure?

300
Pregnancy category X
What is valproate?
300
Schedule V; requires EKG monitoring
What is lacosamide (Vimpat)?
300

Stroke, brain tumor, hypoglycemia, hyponatremia

What are seizure causes (etiology) in older adults?

400
Seizure lasting 5 minutes or longer
What is status epilepticus?
400

Historically has been called "Grand Mal Seizure"

What is generalized tonic-clonic seizure?

400
Black Box Warning for cardiotoxicity; do not infuse more than 50mg/min; must use liner filter; vesicant
What is phenytoin (Dilantin)?
400
No lab monitoring required; minimal DDIs; thought to have fewer mood side effects compared to it's "cousin"
What is brivaracetam?
400

Phenobarbital, primidone, carbamazepine, phenytoin

What are potent CYP inducers?

500
Seizure-free for at least 2 years; normal neuro exam, IQ, and EEG with treatment; single seizure type
What is the AAN criteria for AED withdrawal?
500

Seizure begins in one brain hemisphere; no loss of consciousness; maintains control of motor function

What is simple partial seizure?

500
In status epilepticus, this is 1st line drug of choice for IV administration
What is lorazepam (Ativan)?
500
Glaucoma, nephrolithiasis, oliogohydrosis
What are side effects of topiramate?
500
Components of a BMP
What is Na, Cl, BUN, K, CO2, SCr, glucose?
M
e
n
u