Pathophysiology
Two or more of the following: Temp >38C or <36C, HR >90bpm, RR >20bpm or PaCO2 <32mmHg, WBC >12,000, <4,000
What is systemic inflammatory response syndrome (SIRS)?
Lactate Levels, Blood Cultures, Antibiotics, Fluids
What are the 3-hour sepsis bundle elements
Required prior to antibiotic administration
What are blood cultures x 2
Target SBP and MAP
What is >90 SBP and >65 MAP
SIRS with evidence of infection
What is simple Sepsis
What should not be delayed when treating sepsis patients?
What is the administration of broad-spectrum antibiotics?
This is a marker of tissue perfusion, can be elevated in sepsis
What is lactate?
Name one criteria of acute respiratory organ dysfunction that would qualify a patient for severe sepsis
What is mechanical ventilation- Vent, CPAP, BIPAP
Sepsis associated with organ dysfunction, hypoperfusion, or hypotension
What is Severe Sepsis
Administer vasopressors if MAP <65 or SBP <90 and Repeat lactate level
What are the 6 Hour bundle elements?
Repeat level needs to be collected within 6 hours of sepsis time zero
What is lactate?
Zosyn and Vancomycin are often ordered simultaneously. If you have a line access issue, this medication should be given first
What is Zosyn?
Sepsis with hypotension despite adequate fluid resuscitation with the presence of perfusion abnormalities
What is septic Shock
Fluid Resuscitation amount using LR or NS
What is 30ml/kg?
Blood panel drawn to look at differentiated blood counts and can show possible infections or clotting disorders
What is CBC
This is the number one organ failure found in sepsis.
What is kidney failure?
Presence of viable bacteria in the blood
What is bacteremia/septicemia?
Is started after patient has gotten sepsis fluids and has persistent hypotension
What is vasopressors?
This is the reason that Lactic Acid elevates in Sepsis
What is tissue hypoperfusion?
I do not have to be confirmed in order for the RN to answer YES when considering whether or not I am present
What is infection?