What
What is Paget's disease?
A chronic bone disorder characterized by abnormal bone remodeling, leading to deformed, weak, and fragile bones
Why is early diagnosis of sickle cell disease important?
it allows for the timely initiation of preventive treatments and interventions that significantly reduce the risk of life-threatening complications.
How does sickle cell disease affect red blood cells?
They damage red blood cells and make them hard and sticky causing them to clump together
Is sickle cell curable?
Yes but only in certain cases
What is Sickle Cell?
An inherited blood disorder that affects the shape of red blood cells
Why is early diagnosis of Paget's disease important?
Early diagnosis of Paget's disease is important to prevent severe complications like hearing loss, arthritis, fractures, and bone cancer.
How is Paget's disease diagnosed?
Physical exams, imaging tests, and blood tests.
Is Paget's disease curable
No
What causes sickle cell disease?
A mutation in the HBB gene
Why should you be worried about Sickle Cell?
its potential for causing chronic pain, organ damage (like kidneys, lungs, and spleen), and serious complications such as strokes, severe anemia, and infections.
How is sickle cell disease diagnosed?
Newborn screening, blood tests, and DNA analysis.
What treatments are available for people living with sickle cell disease?
disease-modifying medicines like Hydroxyurea, L-glutamine, and voxelotor, which help reduce symptoms and prevent complications.
Whats causes Paget's disease?
The exact cause is unknown
Why should you be worried about Paget's Disease?
it causes bones to become misshapen, weak, and fragile, increasing the risk of fractures, arthritis, and other complications.
How can sickle cell disease impact mental health?
the emotional toll of living with a chronic illness, leading to higher rates of depression, anxiety, and PTSD. Other factors like family stress, stigma, misunderstanding from healthcare providers, and unmet basic needs can further contribute
What treatments are available for people living with Paget's disease?
medications like potent bisphosphonates (e.g., zoledronic acid) to control abnormal bone growth, supportive therapies such as physiotherapy and occupational therapy to manage pain and improve function.
What complications can arise from sickle cell disease?
acute chest syndrome, anemia, infections, pain crises, stroke, organ damage to the heart, kidneys, and spleen, and eye problems.
How does Paget’s disease affect the structure of bones?
disrupts normal bone remodeling, causing excessive bone breakdown by overactive cells called osteoclasts followed by rapid but disorganized new bone formation by osteoblasts.
Why is sickle cell disease more common in people of African, Mediterranean, Middle Eastern, and Indian ancestry?
the sickle cell trait offers resistance to malaria, which is common in those places
What is bone marrow (or stem cell) transplant and how does it relate to sickle cell treatment?
replaces a patient's unhealthy bone marrow stem cells with healthy ones from a donor, aiming to produce healthy red blood cells and potentially cure sickle cell disease.