NO Signaling
What activates guanylate cyclase?
Nitric Oxide (NO)
Where is the nuclear receptor located?
Cytoplasm or nucleus
Where is the nerve terminal on a neuron?
At end of the axon
What effect does the proteasome have on Notch signaling?
No effect, cleaved by y-secretase
How are STATs activated?
Tyrosine phosphorylation
What does guanylate cyclase make?
What is different about nuclear receptor ligands vs ligands for RTKs and GPCRs?
Cross the plasma membrane
Which voltage-gated channel is important for propagating action potentials?
Sodium channels
What effect does a proteasome inhibitor have on NFKB signaling?
Inhibits NFKB activation (IKB not destroyed)
How is Smad3 activated?
Serine phosphorylation
How does NO get into a cell?
Diffuses across membrane
What is a precursor for steroid hormones?
How is the sodium channel opened?
What effect does proteasome inhibition have on the Wnt/b-catenin pathway?
Activation of b-catenin (b-catenin not degraded)
How is adenylyl cyclase activated?
Galpha-s
What does cGMP activate?
PKG
Where does the nuclear receptor bind its ligand?
In cytoplasm or nucleus
What kind of channel is found in the nerve terminal and is involved in neurotransmitter release?
Voltage-gated Ca+2 channel
What happens to Groucho with proteasome inhibition?
Loss of binding to DNA since b-catenin binds
Is phosphorylation activating or inhibiting?
It can be both depending on the site
What does the cGMP phosphodiesterase do?
Convert cGMP to GMP - turns off signal
What part of the nuclear receptor binds DNA?
Zinc fingers
What type of channel is found on the postsynaptic cell that responds to the neurotransmitter?
Ligand (neurotransmitter) gated channel
What signal sequences are on Delta?
ER signal sequence and stop transfer sequence
What types of activation are in the pathway going from EGF to MAPK?
Tyrosine phosphorylation, GTP binding, serine phosphorylation