Clinical Presentation and Diagnosis of Soft Tissue Infections
First-Line and Empiric Antibiotic Choices
Special Considerations and Complicated Cases
Musicals
100

This non-purulent infection presents with tender, warm, bright erythema and tongue-like extensions, often accompanied by fever or chills, and responds best to penicillin.

What is erysipelas?

100

This oral antibiotic is a first-line agent for mild nonpurulent cellulitis in patients without penicillin allergy. (4)

What is cephalexin? (will accept some others)

100

In patients with severe penicillin allergy, this antibiotic is recommended for Gram-positive coverage in soft tissue infections.

What is clindamycin?

100

Some musicians described being in it as “playing inside a hatbox with legs stomping overhead.”

What is the orchestra pit?

200

Sudden onset of severe pain in an extremity, with or without fever or skin changes, should prompt evaluation for this rapidly progressive, life-threatening infection.

What is necrotizing fasciitis?

200

For purulent cellulitis with risk factors for MRSA, these oral agents are recommended for outpatient therapy. (3)

What are clindamycin, doxycycline, or trimethoprim-sulfamethoxazole?

200

Immunocompromised patients with soft tissue infection require this coverage for atypical, Gram-negative, and anaerobic bacteria?

What is broad-spectrum therapy (e.g., carbapenem or β-lactam/β-lactamase inhibitor)?

200

This show, based on a novel by Gregory Maguire, features characters named Elphaba, Nessarose, and Fiyero.

What is Wicked?

300

This diagnosis is made clinically by spreading erythema, swelling, and local tenderness, often with fever and malaise, and is most commonly caused by streptococci and S. aureus.

What is cellulitis?

300

Initial empiric therapy for necrotizing soft tissue infection should include this broad-spectrum β-lactam/lactamase plus this coverage for MRSA and anaerobes.(3)

What is piperacillin-tazobactam plus vancomycin and clindamycin?

300

Immunocompromised patients with skin infections require empiric coverage for these additional organisms. (3)

What are atypical, Gram-negative, and anaerobic bacteria?

300

*Daily Double* This Bob Fosse–inspired musical uses a vaudeville-style “trial” to tell the story of Roxie Hart and Velma Kelly.

What is Chicago?

400

The presence of purulent drainage, fluctuance, or abscess formation distinguishes this type of soft tissue infection from nonpurulent cellulitis.

What is a cutaneous abscess?

400

In hospitalized patients with moderate to severe nonpurulent cellulitis, this intravenous agent is preferred unless there is a penicillin allergy.

What is cefazolin?

400

Standard infection-control precautions, including this practice, are a mainstay of MRSA prevention in the outpatient setting.

What is proper and frequent handwashing?

400

This musical set in a Baltimore hair salon tackles integration and includes the number “You Can’t Stop the Beat.”

What is Hairspray?

500

Imaging is most useful for excluding abscesses and this severe infection, but surgical exploration remains the gold standard for diagnosis.

What is necrotizing soft tissue infection?

500

For recurrent cellulitis, daily prophylaxis with this oral antibiotic may be considered.(2)

What is penicillin G or amoxicillin?

500

*Daily Double* In children hospitalized with deep soft tissue infections, adjunctive therapy with this agent may be considered for severe cases.

What is intravenous immunoglobulin?

500

 This composer has won more Tony Awards for Best Score than any other in Broadway history. Recently won a Tony for Best Musical Revival for "Merrily We Roll Along."

Who is Stephen Sondheim?

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