Lab mates
Two people in the room today share the same first name. Name them.
The two Michaels — Michael Safarov and Dr. Michael H. Tirgan
Which cell type have we learned is absent in mouse skin but present in human skin?
Sweat gland cells
How many times does Yvon appear on today's program?
Five — State of the Lab, the opening remarks, Bingo and Beakers host, the closing, and the awards
How many Nobel laureates have been affiliated with the Department of Physiology and Cellular Biophysics?
4 — André Cournand, Eric Kandel, James Rothman, Joachim Frank
What enables animals to develop fur?
By generating multiple hair strands in each follicle and by increasing the number of follicles in the skin
The lab has two research rooms. Which room number is reserved for tissue culture work only?
Room 603
What was the lab's first grant?
The Data Science Institute Grant
What is Yvon's height?
6 feet 2 inches
Three scientists shared the 2008 Nobel Prize in Chemistry for the discovery and development of GFP. Name the one who was — and still is — a Columbia professor.
Martin Chalfie (shared with Osamu Shimomura and Roger Y. Tsien)
Which is better for healing — keeping a wound dry, or keeping it wet?
Wet. Moist wound healing is scientifically proven to be significantly better than letting a wound dry out.
How many of today's speakers are medical students?
Four — Chanpreet Toor, Ego Wong, Eunice Park and Nhuquynh Nguyen
What does RESTRICT-seq stand for?
Repetitive Time-Restricted Editing followed by Sequencing
What was Yvon's first grant at Columbia?
The NIGMS R00
In what year did Japanese researchers first report the repeated DNA sequences later named CRISPR?
1987 — Ishino et al., analyzing the iap gene in E. coli at Osaka University
How many muscle groups contribute to mouse wound healing?
Two — the arrector pili muscle and the panniculus carnosus
Who travelled the farthest to be here today?
Rohaan Sanyal — from California (Atherton)
What was the first research instrument received by the lab?
A -80 °C freezer
What field of science was Yvon's undergraduate research in?
Microbial antibiotic resistance
In what year was Columbia's Department of Physiology — our home department — founded?
1767, at what was then King's College
What is healing by secondary intention?
When a wound heals without stitches or surgical closure (bottom up)
A new biomedical research building is going up beside ours. Name either of the two disease areas its research will target.
Neurodegenerative diseases and cancers — through genetic and genomic science. The building also houses the Columbia Initiative for Cell Engineering and Therapy.
Where was the lab's first manuscript originally submitted?
Patches — to Nature Methods
In what month was Yvon's second child born?
February
CRISPR loci were first characterized in a microbe isolated from what kind of place, and in which country?
The salt marshes of Santa Pola, Spain — Francisco Mojica, University of Alicante, working on Haloferax mediterranei (characterized 1993, named CRISPR in 2001)
Secondary intention has two siblings. Name the other two intentions, and what each one means.
Primary intention — the wound edges are approximated or sutured. Tertiary intention, or delayed primary — the wound is left open deliberately, then closed later.