Pharmacology and MOA
The primary psychoactive component of cannabis
What is THC (tetrahydrocannabinol)?
Cannabis Use Disorder (CUD) is classified in this psychiatric manual.
What is the DSM-5?
The first-line approach to treating CUD involves this type of therapy.
What is cognitive behavioral therapy (CBT)?
Cannabis use can cause an increase in this vital sign.
What is heart rate (tachycardia)?
True or False: Adolescents who use cannabis are at higher risk of developing CUD than adults
What is True?
The non-intoxicating cannabinoid commonly used for medical purposes.
What is cannabidiol (CBD)?
A person must meet at least this many symptoms within a 12-month period to be diagnosed with CUD.
What is two?
True or False: The FDA has approved medications for CUD treatment.
What is False?
Long-term cannabis use is associated with cognitive impairment, particularly affecting this function.
What is memory or executive function?
This mental health disorder is commonly comorbid with CUD.
What is depression or anxiety?
THC exerts its effects by acting on this specific receptor in the brain.
What is CB1 (cannabinoid receptor type 1)?
One key symptom of CUD is an inability to do this despite negative consequences.
What is "cut down or control use"?
This over-the-counter supplement has been studied for reducing cannabis cravings.
What is N-acetylcysteine (NAC)?
Cannabis use increases psychosis risk, especially in individuals with this predisposition.
What is "a family history of schizophrenia"?
The estimated percentage of cannabis users who develop CUD.
What is 9%?
Name one endogenous ligand of the endocannabinoid system.
What is anandamide or 2-AG (2-arachidonoylglycerol)?
Cannabis withdrawal symptoms typically begin within this time frame after cessation.
What is 24-72 hours?
Motivational enhancement therapy (MET) is commonly used to encourage this behavior in patients with CUD.
What is "readiness to change or quit"?
THC is metabolized by this enzyme, which can interact with warfarin and other drugs.
What is CYP2C9?
Cannabis with a high concentration of this compound is more likely to lead to dependence
What is THC?
THC is primarily metabolized in the liver by this enzyme.
CYP2C9
Name three DSM-5 criteria used to diagnose CUD.
What are "craving, withdrawal symptoms, and continued use despite problems"?
Name one off-label prescription medication studied for managing cannabis withdrawal symptoms.
What is gabapentin or dronabinol?
Smoking cannabis can increase the clearance of drugs metabolized by this enzyme, similar to tobacco smoking.
What is CYP1A2?
Individuals with a history of this type of disorder are more likely to develop Cannabis Use Disorder.
What is substance use disorder?