S. aureus
Where does Staph aureus bind to?
binds Fc portion of antibody
What is the mechanism of Sulfamethoxazole?
PABA analog that inhibits dihydropteroate synthase, prevents conversion of PABA to DHF
What is the mechanism of Vancomycin?
binds to D-ala-D-ala, inhibiting cell wall peptidoglycan synthesis
What are the phagocytes of the innate immune system?
Macrophages
Neutrophils
What is Protein A in relation to Staph aureus?
the main virulence factor
What is the mechanism of Trimethoprim?
blocks dihydrofolate reductase, preventing the conversion of DHF to THF
Is vancomycin used to treat MRSA
Yes
Do neutrophils present antigens?
No
Is Staph aureus specifically identified using the catalase test or the coagulase test?
coagulase test
No
How does bacteria acquire resistance to Vancomycin?
What are band cells?
Immature neutrophils
How does MRSA acquire its resistant characteristics?
alters Penicillin binding Protein (PBP)
List some adverse reactions to TMP-SMX
rash, fever, urticaria
Anemia
Stevens-Johnson Syndrome
Type IV Renal Tubular Acidosis - hyperkalemia
photosensitivity
Interstitial Nephritis
Increased warfarin concentrations in blood
What is indicated by a left shift?
increased percentage of band cells