500
This syndrome is associated with a long history of treatment with neuroleptic medications. It often impacts multiple neurotransmitter systems, and can include visible withdrawal symptoms if the neuroleptic medications are suddenly stopped.
What is Neuroleptic Withdrawal Syndrome.
Neuroleptic medications are among the most commonly prescribed with the IDD population. Studies have concluded that individuals with ASD are an "increasingly medicated population," and that once started, treatment most often continues with increasing numbers of psychoactive medications being utilized.
Cessation of neuroleptic drugs after a long, sustained usage can result in neuroleptic withdrawal syndrome. This syndrome has many features in common with a mood disorder including insomnia, annorexia, hyperkinesis, irritability, agitation, etc.
Esbensen, A.J., Greenberg, J.S., Seltzer, M.M. & Aman, M.G. (2009). Longitudinal investigation of psychotropic and non-pyschotropicmedication use among adolescents and adults with autism spectrum disorders. Journal of Autism and Developmental Disorders, 39, 1339–1349