L2: Water & Weak Interactions
L3:Amino acids & Protein Properties
L4:Protein Structures
L5:Fibrous Proteins & Folding
L6:Assisted Protein Folding & Misfolded Diseases
100
Weakest yet most universal intermolecular force
What are Van der Waals / London dispersion forces
100
This amino acid is achiral
What is glycine 
Why is it achiral?
100
True or False: Anti-parallel beta sheets have angled H-bonds
False, they have straight on H-bonds, allowing for stronger interactions than a parallel sheet.
100
Collagen is rich in these amino acids
Proline & Glycine & Hydroxyproline
100
This type of post-translational modification signals for protein degradation
Ubiquitination
200
Describe the entropy of this system: 
What is low entropy / ordered system
200
pKa of the amino and carboxyl group...
What is pKa2 and pKa10
200
A membrane protein is partially outside of the cell and partially inside. We consists of an alpha helix...what kind of property would this helix have?
What is amphipathic?
200
BME or beta-mercaptoethanol disrupts what type of bond
What are S-S, disulfide bonds
200
These exposed patches causes misfolded proteins to aggregate
What are hydrophobic patches
300
Major driving force for protein folding & cell membrane assembly
What are Hydrophobic Interactions
300
This structure allows for the side chains of Tyrosine & Tryptophan to absorb UV light
What is an Aromatic ring
300
This motif is found in CDPKs (Ca2+ dependent protein kinases)
What is an EF Hand?
300
A key event in protein folding is...
What is hydrophobic collapse?
300
Which chaperone prevents aggregation and how?
What is HSP70 & by protecting the hydrophobic patches
400
Water interacting with salt is what type of interaction
What is ion hydration / ion-dipole
400
If pH = pI, the amino acid is exclusively in what form?
What is zwitterion form
400
This motif is useful for transporting hydrophobic molecules such as Vitamin....what is the motif?
What is a beta-barrel & Vitamin A
400
T/F: Proteins only have only folding pathway, that always lead to the native state
False, proteins can have multiple folding pathways, which can lead to intermediates known as molten globules
400
The pulling force to unravel a protein by HSP100 comes from...
What is ATP hydrolysis?
500
A membrane protein that interacts with both inside and outside of the cell is likely to have...
What are amphipathic properties
500
A lab technique used for separating proteins based on size
What is size chromatography
bonus 100 points, explain how this separation technique works
500
How does neuraminidase promote viral replication?
What is cleaving sialic acid?
500
If protein folding decreases entropy...does it violate the second law of thermodynamics...and why?
(2nd law: in any any energy transfer, the total entropy of an isolated system always increases)
No, because the release of water upon protein folding gets released, increasing entropy, which is greater than the decrease of entropy from protein folding.
500
How does the GroEL/GroES accelerate / lead protein folding compared to spontaneous folding?
What is encapsulated folding and hiding of hydrophobic residues? (Open answer)