CCB
APAP
Supportive Care
Substance of Abuse
Random!
100
Two hallmarks of CCB poisoning are _______ and _______
What is hypotension, bradycardia
100
The most common clinical manifestation of acetaminophen toxicity is _________
What is hepatotoxicity
100
In supportive care ABCs, A stands for ________
What is Airway
100
Flake, Candy, and base are common street names for this drug
What is Cocaine
100
Snow seals is a street name used for the combination of these two drugs
Amphetamine and Cocaine
200
These two CCB's cause bradycardia
What is Diltiazem, Verapamil
200
Stage ___ of acetaminophen toxicity is defined as maximal hepatotoxicity with an AST/ALT level greater than ______
What is (Stage III, AST/ALT>10,000 units/L)
200
Gastric emptying is most effective when used as soon as possible, but preferably within _____ hours unless GI motility is slowed
What is 1-2 hours
200
Activation of this cannabinoid receptor, found primarily in the brain, inhibits the release of neurotransmitters causing symptoms like psychoactive effects, analgesia, memory impairment, altered sense of time
What is CB1
200
Cocaine was initially used as an anesthetic for this kind of surgery in the 1880s by Dr. Karl Koller.
What is Eye surgery
300
______ and whole bowel irrigation are used for decontamination of CCB toxicity
What is Activated charcoal
300
The antidote for acetaminophen toxicity is _________ and the best time to use it after ingestion is __________
What is (N-acetylcystine, 4-8 hours)
300
This is the preferred treatment for hyperthermia caused by cocaine
What is External cooling (Ice pack)
300
This drug class is used in the initial treatment of anxiety/agitation/seizure in cannabinoid or cocaine toxicity
What is Benzodiazipine
300
Duration of treatment using IV and PO N-acetylcystine are ____hr IV, or ____ hrs PO
What is 21 hours, 72 hours
400
Your patient gets bradycardia from CCB toxicity. This symptom can be treated using ___ as a first line agent
What is atropine
400
Because acetaminophen is rapidly absorbed from GI tract, _______ is not recommended
What is Gastric emptying
400
Calcium ______ is the preferred form of Calcium for CCB toxicity due to having 3 times the amount of Ca2+ per dose
What is Chloride
400
The clinical manifestations of cocaine toxicity?
What is increase HR, BP, TEMP, metabolism, and feelings of exhilaration and increase energy, mental alertness, tremors , reduced appetite, irritability, anxiety, panic, paranoia, violent behavior, psychosis, weight loss, insomnia, cardiac/cardiovascular complication, stroke, seizures, addiction, restlessness, anxiety, irritability, paranoia, panic attacks, mood disturbances, abnormal repetitive movements
400
Although rare, in Stage __ of acetaminophen toxicity, massive overdose (decreased consciousness, metabolic acidosis, elevated lactate, death) can occur without hepatic injury
What is Stage I
500
Bradycardia is caused by CCB toxicity at the ______ cells located in the myocardium
What is pacemaker
500
10% of acetaminophen is metabolized by CYP enzymes into ____1________, which causes hepatotoxicity. And, ___2_____ breaks down ___1_____ to non-toxic metabolites
What is (1. NAPQI, 2. Glutathione)
500
This vasopressor has the highest risk of tachycardia
What is Dopamine
500
Cocaine's mechanism of action is by inhibition of _______ by blocking monoamine transporters
What is reuptake of monoamine
500
The minimum Toxic dose of acetaminophen is greater than ______ for adults, and ______ for children
What is >7.5g, 150mg/kg
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