Sn2
What happens to the stereochemistry in an Sn2 Reaction?
What is Inversion/It flips/Swaps
What happens to the stereochemistry in an Sn1 Reaction?
For E2 reactions, when reacting with a big bulky (sterically hindered) base, the major product will be the
Hoffman product
E1 reactions will always have what product as their major product?
Zaitsev product
E2 Reaction
For an Sn2 reaction, list the favorable conditions for the substrate degree, nucleophile, and solvent
Primary; Strong, Polar Aprotic
For an Sn1 reaction, list the favorable conditions for the substrate degree, nucleophile, and solvent
Tertiary; unaffected; Polar Protic
For an E2 reaction, list the favorable conditions for the substrate degree, base, and solvent
Tertiary; strong; unaffected
For an E1 reaction, list the favorable conditions for the substrate degree, base, and solvent
Tertiary; weak; unaffected
What type of reaction is shown? (Swap to slide 5 cause the jeopardy creator wouldn't allow images to be inserted)
E1 & Sn1
The letters/numbers in SN2 each stands for a specific thing, what does each thing stand for?
Substitution
Nucleophilic / Nucleophile
bimolecular (rate)
In an Sn1 reaction, you form a carbocation intermediate, which allows for this
Hydride/Alkyl Shift
For an E2 reaction, you need an adjacent (beta) H to be in what position compared to the halogen
Anti-Periplanar Position / Anti Position
In an E1 reaction you form this type of intermediate
Carbocation
What type of reaction is shown? (Swap to slide 6 cause the jeopardy creator wouldn't allow images to be inserted)
Sn2
What is the rate of an Sn2 reaction?
Rate=k[sub][Nu]
What is the rate of an Sn1 reaction?
Rate=k[sub]
What is the rate of an E2 reaction?
Rate=k[sub][Base]
What is the rate of an E1 reaction?
Rate=k[sub]
What type of reaction is shown? (Swap to slide 7 cause the jeopardy creator wouldn't allow images to be inserted)
Allylic Bromination
Draw the mechanism for a typical Sn2 reaction using LG for the leaving group, Nu for the nucleophille, B for the base, and R for any Carbon groups off the alpha carbon.
1 step:
Nu --> alpha carbon
alpha carbon bond to LG --> LG
Draw the mechanism for a typical Sn1 reaction using LG for the leaving group, Nu for the nucleophille, B for the base, and R for any Carbon groups off the alpha carbon.
2/3 steps:
Step 1: LG leaves
Step 2: Nu attacks carbocation intermediate
Step 3 (occurs sometimes): 2nd Nu deprotonates product from step 2
Draw the mechanism for a typical E2 reaction using LG for the leaving group, Nu for the nucleophille, B for the base, and R for any Carbon groups off the alpha carbon.
1 Step:
Base attacks beta hydrogen
Beta H-Beta C --> Alpha C-Beta C
Leaving group leaves
Draw the mechanism for a typical E1 reaction using LG for the leaving group, Nu for the nucleophille, B for the base, and R for any Carbon groups off the alpha carbon.
2 Steps:
1st Step: LG leaves
2nd Step: base attacks beta hydrogen
beta H-beta C -->alpha C-beta C
What type of reaction is shown? (Swap to slide 8 cause the jeopardy creator wouldn't allow images to be inserted)
E2