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These are the Incidence and prevalence rates of SLE in North America
What are an Incidence of 23.2 per 100,1000 person-years and a Prevalence of 241 per 100,000 people?
This medication is considered safe for ongoing use during pregnancy in patients with Systemic Lupus Erythematosus (SLE)
What is Hydroxychloroquine?
This standardized tool is utilized to evaluate the severity of Systemic Lupus Erythematosus (SLE) disease
What is the SLEDAI-2K
This agent is used in the treatment of refractory thrombocytopenia in SLE.
What is Rituximab?
This is SLEDAI-2K score is the target low disease activity score treatment goal in SLE patients.
What is a score of 3 or less while on antimalarials?
Concomitant use of this medication along with Hydroxychloroquine increases retinal toxicity.
What is Tamoxifen?
These two agents are recommended for the initial treatment of lupus nephritis as part of induction therapy.
What are mycophenolate mofetil and cyclophosphamide?
List three first-line agents for treatment of MSK manifestations of SLE.
What are NSAIDs, Hydroxychloroquine, and glucocorticoids?
List at least three less common symptoms with which SLE can present.
What are a malar rash, photosensitivity with associated acute or subacute cutaneous lupus rash, pleuritic chest pain, Raynaud phenomenon, and mouth sores?
This is an obligatory entry criterion for the 2019 EULAR/ACR clinical criteria.
What is an ANA titer of 1:80 or more?
These diagnostic procedures are recommended to exclude the presence of preexisting maculopathy prior to the initiation of Hydroxychloroquine
What are baseline fundoscopy, visual field testing, and Spectral-domain optical coherence?
Mycophenolate mofetil should be discontinued at this point if a patient is intending to conceive?
What is 6 weeks prior to the conception?
These are the classification approaches used for systemic lupus erythematosus (SLE)
What are the ACR criteria (1997), the SLICC criteria (2012), and the EULAR/ACR criteria (2019)?
A weighted score greater than this is required to meet EULAR/ACR classification criteria?
What is 10 or more?
These antibodies, if present in female patients with SLE, can exert cardiotoxic effects on the fetus.
What are anti – Ro and anti – La antibodies?
These patients are more likely to respond to Biologic agents
Who are patients with high disease activity, are taking a prednisone dosage of more than 7.5 mg per day, and have serologic activity (low C3/C4, high anti-dsDNA Ab titer)?
These are common nonspecific symptoms experienced by patients with systemic lupus erythematosus (SLE) that often make diagnosis challenging. (Need 4)
What are fatigue, weight loss, fever without source of infection, and joint pain?
List at least 5 of the most common medications associated with drug-induced Lupus erythematosus.
What are hydralazine, isoniazid, procainamide, TNF alpha inhibitors (etanercept, infliximab and adalimumab), minocycline, and quinidine?
List a drug recently approved by the U.S. Food and Drug Administration in 2021 for the management of moderate and severe Systemic Lupus Erythematosus (SLE), as well as its mechanism of action (MOA).
What is anifrolumab (Saphnelo)? It is an Immunoglobulin gamma 1 kappa MAB antagonist of the type 1 interferon receptor.
These four agents are used to treat the integumentary manifestations of SLE that are refractory to first line agents.
What are methotrexate, retinoids, dapsone, and mycophenolate mofetil?