MDS
Mention 1 mechanism involved in mutation driver genes in MDS
• RNA splicing
• DNA methylation
• Histone modification
• Transcription regulation
• DNA repair control
• Signaling
• Cohesin complex
The culprit that start a lot of neuronal malignancy
NF1 mutation
Main treatment of PV is…
Phlebotomy and aspirin
"Say no to HR, Hello NHEJ!" says mutated______
BRCA
How many % of blast is diagnostic for AML?
>20%
This type of MDS has good prognosis due to high response to lenalidomide
MDS Isolated del(5q)
I lost my twin, now I'm going crazy and will bring you down with me.
what phenomenon am I?
LoH
Peripheral blood smear morphology we see in PMF?
Teardrop cell,
leukoerythoblastic
We're twin viral genes that will kill your G1 gate army
E6 & E7
CBF-AML is related to inhibition of what transcription factor?
RUNX1, CEBPA
Characteristic of MDS with mutation of SF3B1?
1. ring sideroblasts,
2. ineffective erythropoiesis,
3. macrocytic anemia
We are multifunction queens! we have the ability to control your movements, your sense, your digestion, or even your moods
Neuroendocrine
Mention 3 stage of CML and the main differences
Chronic phase, accelerated phase, blast crisis.
The difference is on blast percentage.
I got falsely blamed as an oncogene, yet my mutation actually only tempts you to smoke more!
cholinergic nicotine receptor genes (CHRNA/B)
Explain 2 specific cytochemistry staining for AML
1. Myeloperoxidase positive for myeloperoxidase enzyme in granulocyte;
2. Might see Auer Rod Sudan black staining positive for lipid in the granulocyte