Gene List / Spec Requirements
How many genes are in Tempus xF?
What is 105
Which Tempus assay is ideal for monitoring resistance alterations when tissue is not available?
What is Tempus xF
All 648 genes on the xT panel have full ___ coverage.
What is exon
What is an acceptable collection tube for Tempus xF
What is 2 Streck tubes
Tempus xT assay includes reporting of 55 incidental germline findings according to ACMG guidelines
What is False (46 genes)
How many genes are on the Tempus xF panel?
What is 105 genes
The inclusion of normal -match testing reduces false positives by what percentage?
What is 28%
What is the depth of coverage for xT tumor sequencing?
What stage of cancer is xF positioned for?
What is stage IV, advanced/ metastatic
Tempus xT can detect only NTRK1 or NTRK3 gene fusions by DNA
What is False (detects all three by DNA)
How many slides are required for Tempus xT +IHC's
What is 20 slides
Is longitudinal testing billed to insurance?
What is not if it meets second testing criteria
What is an acceptable normal sample for lymphoma?
What is saliva
Why is brain cancer not a preferred subtype for liquid biopsy?
What is the blood brain barrier / tumor doesn't shed into the blood as readily
Fine needle aspirates are ideal specimens for xT sequencing
What is False
How many gene rearrangements are called on Tempus xT panel?
What is 23 genes
What is the clinical advantage of including whole transcriptome RNA sequencing in the xT platform?
What is unbiased novel fusion calling
What is the depth of coverage for germline xT sequencing?
What is 150x
What is the depth of coverage for xF sequencing?
What is 5000x
Patients approved for FAA will not have xF longitudinal testing billed to their insurance
What is False - FA covers OOP costs, but the testing will be billed to insurance
How many rearrangements are on the xF panel?
What is 7
Aside from greater accuracy of somatic mutation calls, what other 3 benefits does the match -normal specimen have?
What is
-reduced provenance errors
- more accurate TMB/MSI
-incidental germline findings,
-conversion to xF
What is the minimal tumor percentage to be submitted for xT?
What is 20%
What MSI status (if any) is reported on xF?
What is MSI-H
Tempus accepts cytology specimens submitted as smears