The Basics
PK/PD
Activity and Resistance
Clinical Uses
ADE
100
Halting the bugs in their tracks!
What is bacteriostatic
100
This tetracycline can have absorption reduced by 50% if taken with food.
What is Tetracycline HCL
100
This bug grows green on blood agar
What is step pneumo
100
This bacteria can be the beign of a teenager's existence.
What is Propionibacterium acnes
100
Chelation with this element make tetracyclines "bad to the bone".
What is calcium
200
OmpF and OmpC are examples of _________, which tetrayclines use to enter the outer membrane of gram negative organisms.
What are porin channels
200
Tetracycline PD parameter.
What is Time>MIC
200
Lighting round!!! Be able to correctly name 4/5 potential resistance mechanisms for this drug class.
1) efflux 2) ribosomal protection proteins 3) enzymatic degradation 4) decreased drug permeability 5) target mutation
200
Name 1/3 FDA approved indications for tigecycline.
1) cSSTI 2) cIAI 3) CAP
200
FDA assessment of risk to fetal harm, specifically for tetracyclines.
What is pregnancy category D
300
This "virulence factor" of bacteria can be reduced with the administration of this drug class.
What is adhesion
300
Not a physical space, a dilution space.
What is volume of distribution
300
Two early generation tetracyclines that efflux pumps typically don't confer to.
What are doxycycline and minocycline
300
Second line agent for this infection. Typically triple or quadruple therapy.
What is Helicobacter Pylori
300
This side effect can leave you black & blue. Particularly with minocycline.
What is hyperpigmentation
400
Name that drug! (see image)
What is tigecycline
400
Tetracycline with the lowest urine concentration, despite what its name may imply.
What is minocycline
400
Over 20 of them exists...examples are tet(O) and tet(M) (P.S. they cause resistance)
What are ribosomal protection proteins (RPP)s
400
The tetracycline with a primary clinical use outside of the realm of infection disease.
What is demeclocycline.
400
The organ that lead to the removal of IV tetracycline hcl from the U.S. market.
What is the liver
500
Variations to carbons ___, ___, and ___ can cause variations in drug proterties between the different tetracyclines.
What is 5, 6, and 7
500
Bug with the lowest MIC breakpoint to the tetracycline class.
What is neisseria gonorrhoeae
500
When is comes to this gene that causes nasty resistance, "X" marks the spot.
What is tet (X)
500
The rickettsial disease not prevalent in Kansas, but extremely prevalent in our neighboring states (Oklahoma, Arkansas, Missouri).
What is Rocky Mountain Spotted Fever
500
The black box warning given to tigecycline by the FDA.
What is increased risk of death
M
e
n
u