The Brain
Substance use
Hormones
Withdrawal and recovery
Bonus
100

This part of the brain controls judgment, planning, decision-making, impulse control, and personality.

What is the frontal lobe?

100

Long-term heavy alcohol use can cause problems with this cognitive function.

memory

100

This gland releases hormones that regulate many other endocrine glands.

What is the pituitary gland?

100

This is the physical and/or psychological response that can occur when substance use is reduced or stopped.

What is withdrawal?

100

Repeated substance exposure can change this brain system, making natural rewards less satisfying and substance cravings stronger.

What is the reward system?

200

This part of the brain controls balance, coordination, posture, and fine motor control.

What is the cerebellum?

200

 Long-term use of this type of drug can contribute to dependence, withdrawal, memory problems, cognitive impairment, and reduced coordination.

What are benzodiazepines?

200

This hormone is an important stress hormone.

What is cortisol?

200

This means needing more of a substance to produce the same effect.

What is tolerance?

200

What brain structure is the key connection between the nervous system and the endocrine system?

 What is the hypothalamus?

300

This part of the brain is involved in hearing, memory, emotions, and language.

 What is the temporal lobe?

300

 Frequent heavy use of this drug can affect memory, attention, learning, coordination, and reward processing.

Cannabis

300

This axis is the hypothalamus–pituitary–adrenal stress pathway.

 What is the HPA axis?

300

 This means the body has adapted to a substance and may experience withdrawal when it is stopped.


What is dependence?

300

 A person experiences changes in fear, emotions, and stress responses. Which brain structure is associated with these functions?

What is the amygdala?

400

 This structure is involved in learning and memory.

What is the hippocampus?

400

 Alcohol can suppress this hormone, which contributes to increased urination.

What is ADH (antidiuretic hormone/vasopressin)?

400

 This axis is the hypothalamus–pituitary–gonadal reproductive hormone pathway.

 What is the HPG axis?

400

This is the brain's ability to change, adapt, and reorganize its connections.

What is neuroplasticity?

400

A person has long-term alcohol use. Alcohol has affected their reward system, memory, decision-making, stress response, and hormone regulation. They stop drinking and experience withdrawal. After withdrawal, they remain abstinent and gradually begin experiencing improvements in sleep, cognition, and emotional regulation.

 What is neuroplasticity?

500

 This structure regulates hunger, thirst, temperature, sleep, stress, and hormone regulation.

What is the hypothalamus?

500

Alcohol is classified as this type of drug.

What is a central nervous system depressant?

500

The HPG axis includes GnRH, LH, FSH, and these three reproductive hormones.

What are estrogen, progesterone, and testosterone?

500

With continued recovery, these brain functions may improve, including planning, judgment, decision-making, impulse control, and emotional regulation.

What is executive function?


500

Put this reproductive pathway in the correct order: LH/FSH, ovaries/testes, hypothalamus, GnRH, pituitary gland.

Hypothalamus → GnRH → Pituitary gland → LH/FSH → Ovaries/Testes

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