Keepin' It Classy (Drug Class/MOA)
Fluconazole is a member of this antifungal class
What are the azoles?
This is the azole drug of choice for a pulmonary Aspergillosis infection.
What is voriconazole?
This form of itraconazole should be taken with food.
What is itraconazole capsules?
Hypokalemia and hypomagnesemia are common side effects seen with this antifungal medication.
What is amphotericin B?
The brand name for fluconazole is this.
What is Diflucan?
Caspofungin is a member of this antifungal class.
What are echinocandins?
Fluconazole does not possess any activity against this species of Candida.
What is Candida krusei?
This azole antifungal agent's absorption is maximized when taken with a high-fat meal.
What is posaconazole?
Patients on agents from this class should be monitored for drug interactions that could cause QTc prolongation.
What are the azoles?
The brand name for voriconazole is this.
What is Vfend?
This antifungal works by targeting lanosterol demethylase to decrease ergosterol synthesis and inhibit cell membrane formation
What are azoles?
These two azoles have activity against Mucor species.
What is posaconazole and isavuconazole?
This drug's absorption is dependent on gastric acidity.
What is itraconazole?
Visual disturbances (e.g. blurred vision, color changes, photopsia) can be seen in up to 30% of patients on this azole antifungal agent.
What is voriconazole?
Noxafil is the brand name for this antifungal agent
What is posaconazole?
This antifungal agent works by binding to ergosterol in cell membranes of fungi thereby causing changes in membrane permeability.
What is amphotericin B?
This Candida species is susceptible to azoles at higher doses only.
What is Candida glabrata?
Name the dosing regimen for posaconazole tablet when it's used as prophylaxis for invasive Aspergillus and Candida infections in immunocompromised patients.
What is 300 mg Q12Hx2 doses then 300 mg Q24H ?
Azole antifungals are inhibitors of this enzyme, causing significant potential DDIs with other medications.
What is CYP3A4?
The brand name for itraconazole is this.
What is Sporanox?
This class of antifungal agents work by inhibiting 1,3-B-glucan synthesis.
What are echinocandins?
This azole is not effective against Aspergillosis
What is fluconazole?
IV administration of some azole antifungals should be used with caution in patients with a CrCl < 50mL/min due to the presence of this compound in the IV formulation.
What is cyclodextrin?
This antifungal has the narrowest spectrum and is also generally the most well tolerated, with minimal adverse effects noted.
What is micafungin?
The brand name for liposomal amphotericin B is this.
What is AmBisome?