Remodeling Phase
What is another name for the remodeling phase of healing?
Maturation phase
When does the fibroblastic repair phase typically begin?
3-4 days post injury
What are the 3 components of granulation tisue?
new capillaries, fibroblasts, and the extracellular matrix
What is the initial type of collagen produced by fibroblasts during the repair phase?
What are the five cardinal signs of inflammation?
Redness, heat, swelling, pain, loss of function.
When does the remodeling phase typically begin?
3-6 weeks post injury
What marks the transition from the inflammatory phase to the repair phase?
The appearance of granulation tissue and new capillaries
Why is angiogenesis important for the formation of granulation tissue?
Provide oxygen and nutrients to the healing area.
Why is type III collagen eventually replaced by type I collagen?
Type I collagen is stronger and more organized.
What is theh function of inflammation during the healing process
containing pathogens, clearing debris, promoting cell repair
What happens to collagen during the remodeling phase?
Type III collagen is replaced by stronger type I collagen
How long does the repair phase usually last?
About 3-6 weeks.
What gives granulation tissue its red appearance?
The presence of new blood vessels.
How do fibroblasts contribute to wound contraction?
Transforming into myofibroblasts that contract to shrink the wound.
Why does vasodilation occur during the inflammatory phase?
Why is the alignment of collagen fibers important during the remodeling phase?
Improve tensile strength and functionality of the tissue
What is the primary function of the repair phase?
To rebuild and strengthen damaged tissue.
What is the extracellular matrix's role in granulation tissue?
Provide structural support for tissue repair.
What is collagen's primary role in tissue healing?
To provide structure and strength to tissue.
Which cells are recruited to clear debris during inflammation?
Neutrophils and macrophages.
How does the tissue's appearance and function change by the end of the remodeling phase?
The tissue becomes more organized, lighter, stronger, and better suited for normal function.
Which cells secrete the extracellular matrix during this phase?
Fibroblasts.
How would tissue repair be affected without granulation tissue?
Healing would be slower and less structured.
What process increases the tensile strength of collagen during repair phase?
Cross-linking
How does chronic inflammation differ from acute inflammation?
Chronic inflammation can damage tissue and acute inflammation helps in recovery and reduces infection.